Association of anti-topoisomerase I with cancer.
Association of anti-topoisomerase I with cancer.
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抗拓扑异构酶 I 与癌症的关联。
DOI：
10.1002/art.1780350621
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发表时间：
1992
影响因子：
--
通讯作者：
Greenberg,B
中科院分区：
文献类型：
--
作者：
Rothfield,N;Kurtzman,S;Vazques-Abad,D;Charron,C;Daniels,L;Greenberg,B
我们以前曾报道过抗拓扑异构酶I的存在与硬皮病患者的癌症之间存在联系[1]。我们目前正在为148名符合美国风湿病学会（前身为美国风湿病协会）硬皮病分类标准的患者提供随访护理（2）。到目前为止，36例抗拓扑异构酶I阳性硬皮病患者中有7例患有癌症，而112例抗拓扑异构酶I阴性患者中有2例患有癌症（2= 11.94，P= 0.0005，比值比13.27，95%置信限2.33-57.5）。在7例抗拓扑异构酶I阳性硬皮病患者中，4例为肺癌，1例为结肠癌，1例为淋巴细胞性淋巴瘤，1例为原发部位不明的转移性脑癌。3名男性和4名女性;他们的年龄范围为33至61岁（平均50岁）。在2例发生癌症的无抗拓扑异构酶I的硬皮病患者中，1例患者在诊断硬皮病前1年患有卵巢癌，另1例患者在诊断CKEST综合征（钙质沉着症、雷诺现象、食管动力障碍、指硬化症、毛细血管扩张症）后10年患口腔癌。这两名患者都是女性;他们在研究时的年龄分别为62岁和57岁。
We have previously reported an association be1 ween the presence of anti-topoisomerase I and cancer in patients with scleroderma (1). We are currently providing followup care for 148 patients who meet the American College of Rheumatology (formerly, the American Rheumatism Association) criteria for the classification of scleroderma (2). Thus far, 7 of 36 anti-topoisomerase I-positive scleroderma patients have had cancer, compared with 2 of 112 negative for anti-topoisomerase I (2= 11.94, P= 0.0005, odds ratio 13.27, at 95% confidence limits 2.33-57.5). The antibody was present in all of these patients prior to the diagnosis of cancer.Of the 7 anti-topoisomerase I-positive scleroderma patients with cancer, 4 had lung cancer, 1 had colon cancer, 1 had lymphocytic lymphoma, and 1 had metastatic brain cancer, with the primary site unknown. Three were men and 4 were women; their ages ranged from 33 to 61 (mean 50). Of the 2 scleroderma patients without anti-topoisomerase I who developed cancer, 1 patient had ovarian carcinoma 1 year prior to the diagnosis of scleroderma and the other tleveloped oral cancer 10 years after a diagnosis of CKEST syndrome (calcinosis, Raynaud’s phenomenon, esophageal dysmotility, sclerodactyly, telangiectasias). Both patients were women; their ages were 62 and 57 at the time of the study.