Skeletal Muscle Deoxygenation and Its Relationship to Aerobic Capacity During Early and Late Stages of Aging.
Skeletal Muscle Deoxygenation and Its Relationship to Aerobic Capacity During Early and Late Stages of Aging.
复制标题
衰老早期和晚期骨骼肌脱氧及其与有氧能力的关系。
DOI：
10.1007/978-3-030-48238-1_12
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Katsumura T.
中科院分区：
文献类型：
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作者：
Takagi S;Kime R;Murase N;Niwayama M;Sakamoto S;Katsumura T.
本研究的目的是比较老年人（n= 10，年龄：73 ± 3岁）、中年人（n= 9，年龄：50 ± 6岁）和年轻人（n= 10，年龄：25 ± 3岁）在运动过程中的肌肉氧动力学。受试者进行坡道自行车运动，直到筋疲力尽。通过近红外空间分辨光谱法连续监测股外侧肌的肌肉血氧饱和度（SmO 2）和氧合血红蛋白/肌红蛋白（α-oxy-Hb/Mb）、脱氧血红蛋白/肌红蛋白（α-deoxy-Hb/Mb）和总血红蛋白浓度（α-total-Hb）相对于休息时的变化。在一定绝对负荷下，老年组的SmO 2和α-脱氧-Hb/Mb显著低于其他组，而α-脱氧-Hb/Mb、α-总Hb和肺摄氧量（VO 2）在三组间无显著差异。相比之下，有没有显着差异，肌肉O2动态在次极量运动中的中年和青年受试者。肌肉O2动力学可能相对保存在早期阶段的老化，虽然肌肉脱氧增强在后期阶段的老化，可能是由于减少对流O2供应。老年人的SmO 2变化与VO 2峰值呈显著正相关，而中青年人的SmO 2变化与VO 2峰值呈显著负相关。在衰老后期，峰值VO 2的减少可能是由于对流O2转运减弱所致，而峰值VO 2的减少可能是由于衰老早期肌肉O2提取减少所致。
The aim of this study was to compare muscle O2dynamics during exercise among elderly (n= 10, age: 73 ± 3 years), middle-aged (n= 9, age: 50 ± 6 years), and young (n= 10, age: 25 ± 3 years) adults. The subjects performed ramp bicycle exercise until exhaustion. Muscle O2saturation (SmO2) and relative changes from rest in oxygenated hemoglobin/myoglobin (∆oxy-Hb/Mb), deoxygenated hemoglobin/myoglobin (∆deoxy-Hb/Mb), and total hemoglobin concentration (∆total-Hb) were monitored continuously at the vastus lateralis muscle by near-infrared spatial resolved spectroscopy. At given absolute workloads, SmO2and ∆oxy-Hb/Mb were significantly lower in elderly than the other groups, while ∆deoxy-Hb/Mb, ∆total-Hb, and pulmonary O2uptake (VO2) were similar among the three groups. In contrast, there were no significant differences in muscle O2dynamics during submaximal exercise between middle-aged and young subjects. Muscle O2dynamics may be relatively preserved in early stages of aging, although muscle deoxygenation is enhanced in late stages of aging, probably due to reduced convective O2supply. Moreover, change in SmO2was significantly positively correlated with peak VO2in the elderly, while a significant negative relationship was observed in middle-aged and young subjects. In late stages of aging, diminished peak VO2may be caused by attenuated convective O2transport, while reduced peak VO2can be explained by lowered muscle O2extraction in early stages of aging.