Gonadotropins, estradiol, and growth factors regulate epithelial ovarian cancer cell growth.
Gonadotropins, estradiol, and growth factors regulate epithelial ovarian cancer cell growth.
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促性腺激素、雌二醇和生长因子调节上皮性卵巢癌细胞的生长。
DOI：
10.1016/0090-8258(92)90230-g
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发表时间：
1992
影响因子：
4.7
通讯作者：
Meehan,D
中科院分区：
文献类型：
--
作者：
Wimalasena,J;Dostal,R;Meehan,D
间接证据表明，性腺类固醇和促性腺激素可能在上皮性卵巢癌的发生中起作用。在本文报道的研究中，我们从上皮性卵巢癌的网膜转移中建立了17种β-雌二醇（E2）分泌细胞培养物。我们证明，人绒毛膜促性腺激素（hCG），人卵泡刺激素，表皮生长因子（EGF）增加细胞生长的剂量和时间依赖性的方式，而E2抑制细胞生长的纳摩尔范围。表皮生长因子能够部分阻断E2的负面作用; hCG也观察到类似但数量较少的作用。这些结果提供了直接的证据支持促性腺激素、EGF、TGFβ（转化生长因子）和雌二醇可调节转移性上皮性卵巢癌细胞生长的观点。
Indirect evidence suggests that gonadal steroids and gonadotropins may have a role in the genesis of epithelial ovarian cancer. In the studies reported herein, we established 17β-estradiol (E2) secreting cell cultures from an omental metastasis of an epithelial ovarian cancer. We demonstrate that human chorionic gonadotropin (hCG), human follicle-stimulating hormone, and epidermal growth factor (EGF) increased cell growth in a dose- and time-dependent manner, whereas E2inhibited cell growth in the nanomolar range. Epidermal growth factor was able to partially block the negative effect of E2; a similar but quantitatively lesser effect was observed with hCG. These results provide direct evidence to support the view that gonadotropins, EGF, TGFβ (transforming growth factor), and estradiol may modulate growth of metastatic epithelial ovarian cancer cells.