History of the science of dialysis
History of the science of dialysis
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DOI：
10.1159/000169116
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发表时间：
1997-05-01
影响因子：
4.2
通讯作者：
Fellner, SK
中科院分区：
文献类型：
--
作者：
Gottschalk, CW;Fellner, SK
托马斯·格雷厄姆（1805-1869）在气体扩散和液体渗透力的性质方面做出了开创性的工作，他可以被恰当地称为现代透析之父。他研究生物液体通过半透膜的行为的装置清楚地预示了今天临床使用的人工肾。1913年，约翰·阿贝尔（John Abel）和他的同事首次将扩散原理应用于去除活体动物血液中的物质。格奥尔格·哈斯（Georg Haas，1886-1971）并不知道阿贝尔的工作，1924年在德国的吉森镇进行了第一次人体透析。但直到1945年，在荷兰极其困难的战时条件下工作的Willem Johan Kolff才在人类患者中实现了第一次临床成功的血液透析。
Thomas Graham (1805-1869), who is credited with seminal work on the nature of the diffusion of gases and of osmotic forces in fluids, can properly be called the father of modern dialysis. His apparatus to study the behavior of biological fluids through a semipermeable membrane clearly presaged the artificial kidney in clinical use today. In 1913, John Abel and coworkers reported the first application of the principles of diffusion to remove substances from the blood of living animals. Unaware of Abel's work, Georg Haas (1886-1971) performed the first human dialysis in the German town of Giessen in 1924. But it was not until 1945 that Willem Johan Kolff, working under extremely difficult wartime conditions in The Netherlands, achieved the first clinically successful hemodialysis in a human patient.