Simulating patterns of excitation, repolarization and action potential duration with cardiac Bidomain and Monodomain models
Simulating patterns of excitation, repolarization and action potential duration with cardiac Bidomain and Monodomain models
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DOI：
10.1016/j.mbs.2005.04.003
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发表时间：
2005-09-01
影响因子：
4.3
通讯作者：
Taccardi, B
中科院分区：
文献类型：
--
作者：
Colli-Franzone, P;Pavarino, LF;Taccardi, B
并行数值模拟的兴奋和恢复在三维心肌域。模拟是基于各向异性Bidomain和Monodomain模型，包括壁内纤维旋转和正交各向异性或轴对称各向异性的细胞内和细胞外的电导率张量。Bidomain模型由两个反应扩散方程组成，而Monodomain模型由一个反应扩散方程组成。这两种模型都与描述离子电流的I相Luo-Rudy膜模型相耦合。对不同大小的心肌板上的兴奋和复极序列的模拟显示了各向异性电传导和纤维旋转如何影响动作电位时程（APD）的分布。尽管细胞膜具有均匀的固有特性，但仍会发生这种影响。APD色散模式与激发波前的各向异性曲率密切相关。All rights reserved.
Parallel numerical simulations of excitation and recovery in three-dimensional myocardial domains are presented. The simulations are based on the anisotropic Bidomain and Monodomain models, including intramural fiber rotation and orthotropic or axisymmetric anisotropy of the intra- and extra-cellular conductivity tensors. The Bidomain model consist of a system of two reaction-diffusion equations, while the Monodomain model consists of one reaction-diffusion equation. Both models are coupled with the phase I Luo-Rudy membrane model describing the ionic currents. Simulations of excitation and repolarization sequences on myocardial slabs of different sizes show how the distribution of the action potential durations (APD) is influenced by both the anisotropic electrical conduction and the fiber rotation. This influence occurs in spite of the homogeneous intrinsic properties of the cell membrane. The APD dispersion patterns are closely correlated to the anisotropic curvature of the excitation wavefront, (c) 2005 Elsevier Inc. All rights reserved.