Substantial effect of acute hydration on blood pressure in patients with autonomic failure.
Substantial effect of acute hydration on blood pressure in patients with autonomic failure.
复制标题
急性水合对自主神经衰竭患者血压的显着影响。
DOI：
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发表时间：
1987
期刊：
影响因子：
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通讯作者：
F. Boesen
中科院分区：
文献类型：
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作者：
J. Mehlsen;F. Boesen
急性水化对动脉血压水平的影响进行了研究，在10例严重的体位性低血压由于自主神经功能衰竭。血压和心率在仰卧位和60度头向上倾斜的位置进行了测定。在仰卧位测量血浆容量和左心室射血分数。快速输注11 μ L等渗盐水后重复测量。急性水化导致仰卧位平均血压水平升高（P <0.01），尽管所有患者的血浆容量正常。体位性平均血压下降幅度由注射生理盐水前的40 mmHg降至注射生理盐水后的20 mmHg（中位数，P <0.01）。结果表明，正常血浆容量并不能确保自主神经衰竭患者的最佳循环状态。用等渗盐水进行急性水化可用于立即纠正自主神经功能衰竭患者的血压水平，对急性水化的反应可用作这些患者循环状态的指标。
The effect of acute hydration on arterial blood pressure levels was investigated in ten patients with severe postural hypotension due to autonomic failure. Blood pressure and heart rate were determined in the supine and 60-degree head-up tilted position. Plasma volume and left ventricular ejection fraction were measured in the supine position. Measurements were repeated after rapid infusion of 11 of isotonic saline. Acute hydration resulted in increased supine mean blood pressure levels (P less than 0.01) despite normal plasma volumes in all patients. The postural reductions in mean blood pressure were reduced from 40 mmHg before to 20 mmHg after saline (median values, P less than 0.01). The results indicate that normal plasma volumes do not ensure optimal circulatory status in patients with autonomic failure. Acute hydration with isotonic saline may be used for immediate corrections of blood pressure levels in patients with autonomic failure and the response to acute hydration may be used as an indicator of the circulatory status in these patients.