Effects of crocin analogs on ocular blood flow and retinal function.
Effects of crocin analogs on ocular blood flow and retinal function.
复制标题
藏红花素类似物对眼血流量和视网膜功能的影响。
DOI：
10.1089/jop.1999.15.143
复制
发表时间：
1999
影响因子：
2.3
通讯作者：
George C.Y. Chiou
中科院分区：
文献类型：
--
作者：
Bo Xuan;Yue;Na Li;Zhi;George C.Y. Chiou
缺血性视网膜病变和年龄相关性黄斑变性是导致失明的主要眼部疾病。这些疾病的病因部分是由于视网膜和/或脉络膜的血流量减少。从藏红花中分离的藏红花素类似物被发现可以显著增加视网膜和脉络膜的血流量，促进视网膜功能的恢复。血管舒张引起的血流量增加可能会改善视网膜结构的氧合和营养供应。这些结果表明藏红花素类似物可用于治疗缺血性视网膜病变和/或年龄相关性黄斑变性。我们注意到，藏红花素的双糖类似物，如藏红花素-1和藏红花素-2，其效力低于藏红花素的单糖类似物，如藏红花素-3和藏红花素-4，这构成了一个有趣的构效关系。
Ischemic retinopathy and age-related macular degeneration are the leading ocular diseases that cause blindness. The etiology of these diseases is due in part to the reduction of blood flow in the retina and/or choroid. Crocin analogs isolated from Crocus sativus L. were found to significantly increase the blood flow in the retina and choroid and to facilitate retinal function recovery. Increased blood flow due to vasodilation presumably improves oxygenation and nutrient supply of retinal structures. These results indicated that crocin analogs could be used to treat ischemic retinopathy and/or age-related macular degeneration. It was noted that disaccharide analogs of crocin, such as crocin-1 and crocin-2, were less potent than monosaccharide analogs of crocin, such as crocin-3 and crocin-4, constituting an interesting structure-activity relationship.