Central control of upper airway resistance regulating respiratory airflow in mammals
Central control of upper airway resistance regulating respiratory airflow in mammals
复制标题
哺乳动物呼吸气流上呼吸道阻力的中枢控制
DOI：
10.1046/j.1469-7580.2002.00101.x
复制
发表时间：
2002
影响因子：
2.4
通讯作者：
M. Dutschmann
中科院分区：
文献类型：
--
作者：
J. Paton;M. Dutschmann
This article reviews recent studies on the importance of glycine receptors for both the spontaneous and the reflex respiratory modulation of the laryngeal abductors and adductors. Our findings show that strychnine blockade of glycine receptors within the brainstem changes the eupneic three‐phase respiratory pattern into two phases. This has major implications for glottal control: (i) the inspiratory glottic abduction and early expiratory adduction were both compromised – a finding mimicked by 5% hypoxia; (ii) closure of the glottis during defensive upper airway reflexes became intermittent and the reflex apnoea reversed to sustained inspiratory discharge. Based on these data, we predict that periods of prolonged hypoxia, such as those that occur during sleep apnoeas, will constrain inspiratory glottic abduction thereby impeding inhalation.
DOI：
10.1152/jappl.1989.67.3.1171
发表时间：
1989
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Zhou,D;Huang,Q;StJohn,WM;BartlettJr,D
通讯作者：
BartlettJr,D