CORTICAL GLUCOSE-METABOLISM IN HUNTINGTONS-DISEASE
CORTICAL GLUCOSE-METABOLISM IN HUNTINGTONS-DISEASE
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DOI：
10.1212/wnl.42.1.223
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发表时间：
1992-01-01
期刊：
影响因子：
9.9
通讯作者：
HAYDEN, MR
中科院分区：
文献类型：
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作者：
MARTIN, WRW;CLARK, C;HAYDEN, MR
我们用正电子发射断层扫描测量了39例亨廷顿病（HD）患者和34例对照组的皮质糖代谢。在症状持续时间少于5年的23例患者中，额叶和下顶叶皮质代谢下降15%。在16例症状超过5年的患者中，所有皮质区域（颞叶除外）均明显受累，代谢率比对照组低25 - 30%。这些数据表明HD存在弥漫性皮层功能异常，早期累及额叶，提示临床表现可能不仅仅与基底神经节病理有关，即使在疾病早期也是如此。
We measured cortical glucose metabolism with positron emission tomography in 39 patients with Huntington's disease (HD) and in 34 controls. In the 23 patients with symptoms for less than 5 years, there was a 15% decrease in metabolism in frontal and inferior parietal cortex. In 16 patients with symptoms for more than 5 years, all cortical areas (except temporal) were significantly involved, with metabolic rates 25 to 30% below those of controls. These data indicate the presence of a diffuse abnormality of cortical function with early involvement of frontal lobes in HD, suggesting that the clinical manifestations may not be related solely to basal ganglia pathology, even in early disease.