A new family of high-affinity ABC manganese and zinc permeases
A new family of high-affinity ABC manganese and zinc permeases
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DOI：
10.1016/s0923-2508(01)01195-0
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发表时间：
2001-04-01
影响因子：
2.6
通讯作者：
Claverys, JP
中科院分区：
文献类型：
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作者：
Claverys, JP
系统发育分析的47个细胞外推定的金属结合受体（MBR）属于新定义的集群表明存在两个亚群。相应的ATP结合盒（ABC）渗透酶的底物特异性的问题进行了讨论，收集的数据的基础上，从19个关于他们的监管，金属要求的渗透酶突变体，金属吸收和金属结合。建议这两个子集群对应的旁系金属permeases主要致力于锰和锌的运输。作为粘附素的革兰氏阳性菌的MBR的直接作用的问题，然后讨论和金属渗透酶的细胞过程和宿主-细菌相互作用的重要性进行了审查。(C)2001年，Elsevier SAS科学与医学版。
Phylogenetic analysis of 47 extracellular putative metal binding receptors (MBRs) belonging to the newly defined cluster suggests the existence of two subclusters. The question of substrate specificity of the corresponding ATP binding cassette (ABC) permeases is discussed, based on data collected from 19 of them concerning their regulation, metal requirement of permease mutants, metal uptake and metal binding. The proposal that the two subclusters correspond to paralogous metal permeases dedicated primarily to manganese and to zinc transport is made. The question of a direct role of MBRs as adhesins of Gram-positive bacteria is then discussed and the importance of metal permeases for cellular processes and host-bacteria interactions is reviewed. (C) 2001 Editions scientifiques et medicales Elsevier SAS.