CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs
CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs
复制标题
DOI：
10.1016/s0092-8674(00)80059-8
复制
发表时间：
1999-10-01
期刊：
影响因子：
64.5
通讯作者：
Lipp, M
中科院分区：
文献类型：
--
作者：
Förster, R;Schubel, A;Lipp, M
正常的免疫监视功能需要良好的协调机制，以引导巡逻的免疫细胞通过外周组织并进入次级淋巴器官。分析基因靶向小鼠，我们确定趋化因子受体CCR7作为主要免疫应答的重要组织者。CCR7缺陷型小鼠显示出关于抗体应答的严重延迟的动力学，并且缺乏接触敏感性和迟发型超敏反应。由于淋巴细胞迁移受损，这些动物在所有次级淋巴器官中显示出深刻的形态学变化。在激活后，成熟的皮肤树突状细胞不能迁移到引流淋巴结中。因此，为了将淋巴细胞和树突状细胞聚集在一起以形成次级淋巴器官的特征性微结构，需要CCR7来快速启动过继性免疫应答。
The proper function of immune surveillance requires well-coordinated mechanisms in order to guide the patrolling immune cells through peripheral tissues and into secondary lymphoid organs. Analyzing gene-targeted mice, we identified the chemokine receptor CCR7 as an important organizer of the primary immune response. CCR7-deficient mice show severely delayed kinetics regarding the antibody response and lack contact sensitivity and delayed type hypersensitivity reactions. Due to the impaired migration of lymphocytes, these animals reveal profound morphological alterations in all secondary lymphoid organs. Upon activation, mature skin dendritic cells fail to migrate into the draining lymph nodes. Thus, in order to bring together lymphocytes and dendritic cells to form the characteristic microarchitecture of secondary lymphoid organs, CCR7 is required to rapidly initiate an adoptive immune response.