Weight maintenance following the STRIDE lifestyle intervention for individuals taking antipsychotic medications.
Weight maintenance following the STRIDE lifestyle intervention for individuals taking antipsychotic medications.
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DOI：
10.1002/oby.21205
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发表时间：
2015-10
期刊：
影响因子：
--
通讯作者：
Stevens VJ
中科院分区：
文献类型：
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作者：
Green CA;Yarborough BJ;Leo MC;Stumbo SP;Perrin NA;Nichols GA;Stevens VJ
服用抗精神病药物的个体会增加与肥胖相关的早期发病/死亡的风险。本报告介绍了为服用抗精神病药物的人制定的成功减肥和行为生活方式改变计划的体重维持结果。 STRIDE 是一项 2 组随机对照试验。干预参与者参加为期 6 个月的每周小组会议，然后参加为期 6 个月的每月小组会议。评估在基线、6、12 和 24 个月时完成。 24 个月时，干预参与者的体重减轻了 3.7%，对照参与者的体重减轻了 2.1%，差异不显着。空腹血糖结果也遵循类似的模式。然而，空腹胰岛素存在统计学上的显着差异——干预组的水平在强化干预结束时（6 个月）和 24 个月之间有所下降（10.1 至 7.91μU/mL）；在此期间，对照参与者的水平增加（11.66 至 12.92μU/mL）。在干预后 12 至 24 个月的维持期内，干预参与者的住院治疗次数 (5.7%) 也少于对照组 (21.1%；X2=8.47，p=0.004)。干预期后，尽管空腹胰岛素水平继续改善，但各组之间的体重变化差异有所缩小。住院治疗的减少表明，体重减轻，即使体重恢复，也可能对服用抗精神病药物的人产生长期的积极益处，并可能降低费用。
Individuals taking antipsychotic medications have increased risk of obesity-related early morbidity/mortality. This report presents weight maintenance results from a successful weight loss and behavioral lifestyle change program developed for people taking antipsychotic medications. STRIDE was a 2-arm, randomized controlled trial. Intervention participants attended weekly group meetings for 6 months, then monthly group meetings for 6 months. Assessments were completed at baseline, 6, 12, and 24 months. At 24-months, intervention participants lost 3.7% of baseline weight and control participants 2.1%, a non-significant difference. Fasting glucose results followed a similar pattern. There was a statistically significant difference, however, for fasting insulin—the intervention group’s levels decreased between the end of the intensive intervention (at 6 months) and 24 months (10.1 to 7.91μU/mL); control participants’ levels increased (11.66 to 12.92μU/mL) during this period. There were also fewer medical hospitalizations among intervention participants (5.7%) than controls (21.1%; Χ2=8.47, p=0.004) during the 12 to 24-month post-intervention maintenance period. Weight-change differences between arms diminished following the intervention period, though fasting insulin levels continued to improve. Reduced hospitalizations suggest that weight loss, even with regain, may have long-term positive benefits for people taking antipsychotic medications and may reduce costs.