One and one is not two: taking a fresh look at membrane interfaces.
One and one is not two: taking a fresh look at membrane interfaces.
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一加一不是二：重新审视膜界面。
DOI：
10.1038/s41580-018-0057-3
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Fletcher,DanielA
中科院分区：
文献类型：
--
作者：
Belardi,Brian;Fletcher,DanielA
质膜位于细胞内部和外部环境之间的分界线-概念上和字面上-协调附近细胞之间的通信并构建周围组织。虽然过去半个世纪的巨大努力已经推进了我们对质膜分子组织的理解，但大部分工作都集中在不与其他细胞接触的游离质膜上。最近的研究突出了两个细胞之间形成的膜界面的独特和意想不到的特征，其中界面的物理和化学约束共同创造了一个不同于单独的质膜的系统。受这种新兴的细胞-细胞接触的观点的启发，我们建议将细胞之间的界面分类为不同的细胞隔室。
Plasma membranes sit at the divide — conceptually and literally — between the interior and exterior milieu of cells, coordinating communication between nearby cells and structuring surrounding tissue. While great effort over the past half-century has advanced our understanding of the molecular organization of the plasma membrane, much of this work has focused on free plasma membranes that are not in contact with other cells. Recent studies have highlighted unique and unexpected features of membrane interfaces formed between two cells, where the physical and chemical constraints of the interface conspire to create a system that is distinct from either plasma membrane alone. Inspired by this emerging view of cell–cell contacts, we propose classifying interfaces between cells as a distinct cellular compartment.