AC and Phase Sensing of Nanowires for Biosensing.
AC and Phase Sensing of Nanowires for Biosensing.
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DOI：
10.3390/bios6020015
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发表时间：
2016-04-19
期刊：
影响因子：
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通讯作者：
Tartagni M
中科院分区：
文献类型：
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作者：
Crescentini M;Rossi M;Ashburn P;Lombardini M;Sangiorgi E;Morgan H;Tartagni M
硅纳米线是无需标记的传感器，可以进行实时测量。它们经济实惠，为现场护理应用铺平了道路，但需要复杂的读数和熟练的人员。我们提出了一种新的模型和技术，用于使用交流电（AC）来感测纳米线传感器，以捕获来自传感器的幅度和相位信息。这种方法结合了复阻抗谱的优点和锁定技术的降噪性能。实验结果表明，对具有不同表面化学性质的传感器进行修改如何导致相同的直流 (DC) 响应，但可以使用交流方法进行辨别。
Silicon nanowires are label-free sensors that allow real-time measurements. They are economical and pave the road for point-of-care applications but require complex readout and skilled personnel. We propose a new model and technique for sensing nanowire sensors using alternating currents (AC) to capture both magnitude and phase information from the sensor. This approach combines the advantages of complex impedance spectroscopy with the noise reduction performances of lock-in techniques. Experimental results show how modifications of the sensors with different surface chemistries lead to the same direct-current (DC) response but can be discerned using the AC approach.