Design and applications of bispecific heterodimers: molecular imaging and beyond.
Design and applications of bispecific heterodimers: molecular imaging and beyond.
复制标题
DOI：
10.1021/mp500115x
复制
发表时间：
2014-06-02
影响因子：
4.9
通讯作者：
Cai W
中科院分区：
文献类型：
--
作者：
Luo H;Hong H;Yang SP;Cai W
基于配体的分子成像探针被设计为具有高亲和力和特异性，用于监测生物过程和反应。传统探针的单靶点识别可能限制其在疾病检测和治疗中的应用，因为疾病介质和不同受体之间的协同作用通常涉及疾病进展。因此，能够识别多个靶标的探针应该比单特异性探针表现出更高的靶向功效和特异性。这一概念已被多个基于双特异性异二聚体的成像探针所验证，这些探针已在多种动物模型中证明了有希望的结果。本综述总结了基于双特异性肽和抗体的异二聚体的设计策略及其在分子靶向和成像中的应用。还讨论了双特异性异二聚体共轭纳米材料的设计和应用。
Ligand-based molecular imaging probes have been designed with high affinity and specificity for monitoring biological process and responses. Single-target recognition by traditional probes can limit their applicability for disease detection and therapy because synergistic action between disease mediators and different receptors is often involved in disease progression. Consequently, probes that can recognize multiple targets should demonstrate higher targeting efficacy and specificity than their monospecific peers. This concept has been validated by multiple bispecific heterodimer-based imaging probes that have demonstrated promising results in several animal models. This review summarizes the design strategies for bispecific peptide- and antibody-based heterodimers and their applications in molecular targeting and imaging. The design and application of bispecific heterodimer-conjugated nanomaterials are also discussed.
登录
查看更多内容
在梗塞心肌中靶向和固定骨骼衍生的多能细胞的抗MLC1×抗CD90双特异性抗体的合成和评估。
影响因子：
4.7
作者：
Gundlach, C. William;Caivano, Amy;Cabreira-Hansen, Maria da Graca;Gahremanpour, Amir;Brown, Wells S.;Zheng, Yi;McIntyre, Bradley W.;Willerson, James T.;Dixon, Richard A. F.;Perin, Emerson C.;Woodside, Darren G.
通讯作者：
Woodside, Darren G.
DOI：
10.1093/protein/12.7.597
发表时间：
1999-07-01
期刊：
PROTEIN ENGINEERING
影响因子：
--
作者：
Atwell, JL;Breheney, KA;Hudson, PJ
通讯作者：
Hudson, PJ
影响因子：
50.3
作者：
Agus, DB;Akita, RW;Sliwkowski, MX
通讯作者：
Sliwkowski, MX
影响因子：
4.8
作者：
Gunasekaran, Kannan;Pentony, Martin;Yan, Wei
通讯作者：
Yan, Wei
影响因子：
4.4
作者：
Cochlovius, B;Kipriyanov, SM;Little, M
通讯作者：
Little, M