Association between high-risk HPV types, HLA DRB1*and DQB1*alleles and cervical cancer in British women
Association between high-risk HPV types, HLA DRB1*and DQB1*alleles and cervical cancer in British women
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DOI：
10.1054/bjoc.1999.1103
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发表时间：
2000-04-01
影响因子：
8.8
通讯作者：
Duncan, I
中科院分区：
文献类型：
--
作者：
Cuzick, J;Terry, G;Duncan, I
对116名英国宫颈癌患者的宫颈刮痕进行了高致癌风险人类乳头瘤病毒（HPV）基因型（HPV(hr)）的检测。94%的刮痧有一种或多种这些病毒类型，66%是hpv16阳性。HPV18在腺癌中更为常见。没有证据表明HPV16 E6 350G变异与癌症风险增加有关。将这些妇女和155名细胞学正常、HPV(hr) DNA阴性的妇女的HLA DRB1*和DQB1*等位基因进行比较。DQB1*0301单用（2P = 0.02）及与DRB1*0401合用（2P = 0.02）与宫颈癌相关。这在除HPV16以外的HPV类型阳性的癌症中更为明显。相比之下，DRB1*1501单独和与DQB1*0602联合在癌症中总体上没有显著升高，但在hpv16阳性癌症中确实显示出一些过量（2P = 0.05），与hpv16阳性宫颈癌相关。综合所有癌症，发现DQB1*0501有轻微显著的保护作用（2P = 0.03），而DRB1*1301没有保护作用。(C) 2000癌症研究运动。
Cervical scrapes from 116 British women referred with cervical cancer were tested for the presence of high oncogenic risk human papillomavirus (HPV) genotypes (HPV(hr)). Ninety-four per cent of the scrapes had one or more of these virus types and 66% were HPV16-positive. HPV18 was more frequent in adenocarcinoma. No evidence was found for an increased cancer risk associated with the HPV16 E6 350G variant. The HLA DRB1* and DQB1* alleles in these women and in 155 women with normal cytology and negative for HPV(hr) DNA were compared. DQB1*0301 alone (2P = 0.02) and in combination with DRB1*0401 (2P = 0.02) was found to be associated with cervical cancer. This was more marked in cancers positive for HPV types other than HPV16. In contrast, DRB1*1501 alone and in combination with DQB1*0602 was not significantly elevated in cancers overall, but did show some excess in HPV16-positive cancers (2P = 0.05), associated with HPV16-positive cervical cancers. Taking all cancers together, a marginally significant protective effect was found for DQB1*0501 (2P = 0.03) but no protective effect could be seen for DRB1*1301. (C) 2000 Cancer Research Campaign.