A role for collagen phagocytosis by fibroblasts in scar remodeling: an ultrastructural stereologic study.
A role for collagen phagocytosis by fibroblasts in scar remodeling: an ultrastructural stereologic study.
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成纤维细胞胶原蛋白吞噬作用在疤痕重塑中的作用：超微结构体视学研究。
DOI：
10.1111/1523-1747.ep12519983
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
A. T. Ten Cate
中科院分区：
文献类型：
--
作者：
W. T. McGaw;A. T. Ten Cate
通过对几种以高胶原周转率和重塑为特征的结缔组织的研究表明，成纤维细胞的胶原吞噬和细胞内降解在重塑活动中起到了作用。通过对小鼠皮肤创伤后不同时间成纤维细胞吞噬胶原的超微结构体视学定量测量，研究了这种活性在正常的瘢痕组织重塑中的可能重要性。结果表明，这种吞噬活性的高峰期与胶原纤维跨疤痕发生重定向的时间间隔之间存在相关性。
A role for collagen phagocytosis and intracellular degradation by fibroblasts during remodeling activity has been suggested by studies on several connective tissues characterized by high rates of collagen turnover and remodeling. The possible importance of such activity in the normal remodeling of scar tissue has been studied by a quantitative ultrastructural stereologic measure of collagen phagocytosis by fibroblasts at various post-wounding intervals in mouse skin scars. The results demonstrate a correlation between the peak periods of such phagocytic activity and the interval during which collagen fiber reorientation across the scar appears to take place.