Effects of miR-31 on the osteogenesis of human mesenchymal stem cells
Effects of miR-31 on the osteogenesis of human mesenchymal stem cells
复制标题
miR-31对人间充质干细胞成骨的影响
DOI：
10.1016/j.bbrc.2014.02.058
复制
发表时间：
2014-03-28
影响因子：
3.1
通讯作者：
Fan, Xianqun
中科院分区：
文献类型：
--
作者：
Xie, Qing;Wang, Zi;Fan, Xianqun
探索调控人骨髓间充质干细胞（hMSCs）成骨的分子机制，将为骨相关疾病的治疗带来更有效的方法。在本研究中，我们分析了miR-31对hMSCs成骨的影响。miR-31的过表达抑制hMSCs的成骨作用，而下调miR-31则促进hMSCs的成骨作用。SATB 2被证实是miR-31的直接靶点，并描述了其对成骨的影响。最重要的是，SATB 2的敲低减弱了miR-31的成骨作用。综上所述，我们的研究结果表明，miR-31通过靶向SATB 2调节hMSCs的成骨作用。(C)2014爱思唯尔公司All rights reserved.
Exploring the molecular mechanisms that regulate the osteogenesis of human mesenchymal stem cells (hMSCs) will bring us more efficient methods for improving the treatment of bone-related diseases. In this study, we analyzed the effects of miR-31 on the osteogenesis of hMSCs. The overexpression of miR-31 repressed the osteogenesis of hMSCs, whereas the downregulation enhanced this process. SATB2 was testified to be a direct target of miR-31, and its effects on the osteogenesis were also described. Most importantly, the knockdown of SATB2 attenuated miR-31's osteogenic effects. Taken together, our findings suggest that miR-31 regulates the osteogenesis of hMSCs by targeting SATB2. (C) 2014 Elsevier Inc. All rights reserved.