OPINION Interplay between the TH17 and TReg cell lineages: a (co-)evolutionary perspective
OPINION Interplay between the TH17 and TReg cell lineages: a (co-)evolutionary perspective
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DOI：
10.1038/nri2660
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发表时间：
2009-12-01
影响因子：
100.3
通讯作者：
Hatton, Robin D.
中科院分区：
文献类型：
--
作者：
Weaver, Casey T.;Hatton, Robin D.
适应性免疫系统的起源及其与脊椎动物物种的独特联系的基础一直是一个相当大的猜测来源。鉴于最近我们对诱导调节性T细胞和辅助性T细胞系之间的发育和功能联系以及它们与肠道的特殊关系的了解的最新进展，我们推测这些适应性免疫途径的共同进化可能为原始脊椎动物提供了一种从共生微生物群的多样化中受益的手段。
The origins of the adaptive immune system and the basis for its unique association with vertebrate species have been a source of considerable speculation. In light of recent advances in our understanding of the developmental and functional links between the induced regulatory T cell and T helper 17 cell lineages, and their specialized relationship to the gut, we speculate that the co-evolution of these adaptive immune pathways might have given primitive vertebrates a means to benefit from the diversification of their commensal microbiota.