Impact of unnatural nucleosides on the control of microbial growth.
Impact of unnatural nucleosides on the control of microbial growth.
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DOI：
10.4265/bio.14.55
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发表时间：
2009-06
影响因子：
1.2
通讯作者：
A. Hatano;M. Nishimura;I. Souta
中科院分区：
文献类型：
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作者：
A. Hatano;M. Nishimura;I. Souta
这项研究调查了非天然核苷的抗菌活性。我们测试了 17 种合成核苷类似物对 10 种微生物菌株的 MIC 和 MBC。这些核苷类似物根据其结构特征分为四类。观察到化合物 1-1、3-1 和 4-3 具有抑制作用。特别是，5'-脱氧胸苷 (3-1) 在 50 微克/mL 浓度下对枯草芽孢杆菌和金黄色葡萄球菌最有效。该类似物的 5' 位羟基已被氢原子取代。所有化合物对各种霉菌都有微弱的作用。 5'-脱氧胸苷在 0.5 小时内对金黄色葡萄球菌的 MBC 为 50 g/mL。这些结果表明，5'-脱氧胸苷在 17 种不同的非天然核苷中具有最有效的抗菌活性。 3-1 的抑制作用表明它可能在医疗领域用作抗菌剂。
This research investigated the antimicrobial activities of unnatural nucleosides. We tested the MIC and MBC of 17 synthetic nucleoside analogues against 10 microbial strains. These nucleoside analogues were classified into four groups according to their structural characteristics. Inhibition was observed with compounds 1-1, 3-1, and 4-3. In particular, 5'-deoxythymidine (3-1) was most effective at 50 micro g/mL against Bacillus subtilis and Staphylococcus aureus. This analogue has had the hydroxyl group at the 5' position replaced with a hydrogen atom. All compounds had weak effects against various species of mold. The MBC of 5'-deoxythymidine was 50 g/mL in 0.5 h against S. aureus. These results showed that 5'-deoxythymidine had the most effective antimicrobial activity of the 17 different unnatural nucleosides. The inhibitory effect of 3-1 suggests that it may be useful as an antibacterial agent in medical situations.