INDUCTION OF TRANSPLANTATION IMMUNITY TO RAT COLON-CARCINOMA ISOGRAFTS BY IMPLANTATION OF INTACT FETAL COLON TISSUE
INDUCTION OF TRANSPLANTATION IMMUNITY TO RAT COLON-CARCINOMA ISOGRAFTS BY IMPLANTATION OF INTACT FETAL COLON TISSUE
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DOI：
10.1002/ijc.2910260111
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发表时间：
1980-01-01
影响因子：
6.4
通讯作者：
SJOGREN, HO
中科院分区：
文献类型：
--
作者：
HEDLUND, G;SJOGREN, HO
完整结肠组织对大肠癌同种移植物的免疫诱导被证实。通过在肾包膜下植入丝裂霉素C处理的完整胎鼠结肠组织，使成年大鼠免疫胎鼠抗原。对照动物接受完整成年结肠组织片的植入物。3或5周后取出含有植入物的肾脏，并用1，2-二甲基肼（DMH）诱导的结肠癌的同系移植物对大鼠进行攻击。与对照相比，在免疫组中观察到肿瘤生长的显著抑制。在13-15日龄胎儿的完整结肠组织中表达的一些胚胎-胎儿抗原也在结肠癌细胞中表达，并且可以充当移植抗原。
The induction of immunity in intact colon tissue to large-bowel cancer isografts was demonstrated. Adult rats were immunized against fetal antigens by implantation of mitomycin-C-treated intact fetal colon tissue beneath the renal capsule. Control animals received implants of pieces of intact adult colon tissue. Kidneys containing the implants were removed after 3 or 5 wk and the rats were challenged with isografts of a 1,2-dimethylhydrazine (DMH)-induced colon carcinoma. Significant inhibition of tumor growth was observed in immunized groups compared to controls. Some embryo-fetal antigens expressed in intact colon tissue of 13-15 day old fetuses are also expressed in colon carcinoma cells and can act as transplantation antigens.