Correlation of somatostatin receptor PET/CT imaging features and immunohistochemistry in neuroendocrine tumors of the lung: a retrospective observational study.
Correlation of somatostatin receptor PET/CT imaging features and immunohistochemistry in neuroendocrine tumors of the lung: a retrospective observational study.
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DOI：
10.1007/s00259-022-05848-z
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发表时间：
2022-10
影响因子：
9.1
通讯作者：
Rindi, Guido
中科院分区：
文献类型：
--
作者：
Rufini, Vittoria;Lorusso, Margherita;Inzani, Frediano;Pasciuto, Tina;Triumbari, Elizabeth Katherine Anna;Grillo, Lucia Rosalba;Locco, Filippo;Margaritora, Stefano;Pescarmona, Edoardo;Rindi, Guido
关键词：
回顾性分析一系列肺神经内分泌肿瘤（NET）的生长抑素受体（SSTR）和增殖活性谱（SSTR2、SSTR5、Ki-67）与SSTR- pet /CT成像特征之间的关系。增殖活性与Ki-67和18F-FDG-PET/CT参数（可用时）也相关。在2011年7月至2020年3月期间，551例接受SSTR-PET/CT检查并使用68ga - dota -生长抑素类似物（SSA）治疗肺神经内分泌肿瘤的患者中，32例确诊为NET。其中14例为18F-FDG-PET/CT。对PET/CT图像进行定性和半定量分析。免疫组化检测SSTR2、SSTR5和Ki-67。采用kappa统计和Spearman秩相关检验进行推理分析。最终诊断为26例典型类癌g1和6例非典型类癌g2。SSTR2-IHC阳性率为62.5%，SSTR5-IHC阳性率为19.4%。24/32例SSTR2-IHC与sstr2 - pet /CT有相关性（75.0%,p = 0.003）：一致阳性20例，一致阴性4例。对于IHC阳性，观察到100%的一致性与str - pet /CT（均为阳性），而IHC阴性一致性（均为阴性）为33.3%。在8例中，IHC为阴性，而SSTR-PET/CT为阳性，尽管除1例外，其余均为低级别摄取。SSTR-PET/CT的SUVmax值与SSTR2-IHC评分有显著相关性，SUVmax值低对应于IHC阴性，SUVmax值高对应于IHC阳性（p = 0.002）。这项回顾性研究显示，SSTR2-IHC与肺NETs中sstr2 - pet /CT的肿瘤摄取之间的总体一致性很好。SSTR-PET/CT的SUVmax值可以作为SSTR2密度的参数。在相对较小的队列限制下，我们的数据表明，当无法获得SSTR-PET/CT时，SSTR2-IHC可以代替SSTR-PET/CT在选定的肺NET患者中进行临床决策。
To correlate somatostatin receptor (SSTR) and proliferative activity profile (SSTR2, SSTR5, Ki-67) at immunohistochemistry (IHC) with SSTR-PET/CT imaging features in a retrospective series of lung neuroendocrine tumors (NET). Proliferative activity by Ki-67 and 18F-FDG-PET/CT parameters (when available) were also correlated. Among 551 patients who underwent SSTR-PET/CT with 68Ga-DOTA-somatostatin analogs (SSA) between July 2011 and March 2020 for lung neuroendocrine neoplasms, 32 patients with a confirmed diagnosis of NET were included. For 14 of them, 18F-FDG-PET/CT was available. PET/CT images were reviewed by qualitative and semi-quantitative analyses. Immunohistochemistry for SSTR2, SSTR5, and Ki-67 was assessed. Inferential analysis was performed including kappa statistics and Spearman’s rank correlation test. Definitive diagnosis consisted of 26 typical carcinoids-G1 and six atypical carcinoids-G2. Positive SSTR2-IHC was found in 62.5% of samples while SSTR5-IHC positivity was 19.4%. A correlation between SSTR2-IHC and SSTR-PET/CT was found in 24/32 cases (75.0%, p = 0.003): 20 were concordantly positive, 4 concordantly negative. For positive IHC, 100% concordance with SSTR-PET/CT (both positive) was observed, while for negative IHC concordance (both negative) was 33.3%. In 8 cases, IHC was negative while SSTR-PET/CT was positive, even though with low-grade uptake in all but one. A significant correlation between SUVmax values at SSTR-PET/CT and the SSTR2-IHC scores was found, with low SUVmax values corresponding to negative IHC and higher SUVmax values to positive IHC (p = 0.002). This retrospective study showed an overall good agreement between SSTR2-IHC and tumor uptake at SSTR-PET/CT in lung NETs. SSTR-PET/CT SUVmax values can be used as a parameter of SSTR2 density. Within the limits imposed by the relatively small cohort, our data suggest that SSTR2-IHC may surrogate SSTR-PET/CT in selected lung NET patients for clinical decision making when SSTR-PET/CT is not available.
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影响因子：
50.5
作者：
Righi, L.;Volante, M.;Papotti, M.
通讯作者：
Papotti, M.
影响因子：
5.5
作者：
Hofman, Michael S.;Lau, W. F. Eddie;Hicks, Rodney J.
通讯作者：
Hicks, Rodney J.
DOI：
10.1038/s41379-018-0110-y
发表时间：
2018-12
期刊：
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
影响因子：
--
作者：
Rindi G;Klimstra DS;Abedi-Ardekani B;Asa SL;Bosman FT;Brambilla E;Busam KJ;de Krijger RR;Dietel M;El-Naggar AK;Fernandez-Cuesta L;Klöppel G;McCluggage WG;Moch H;Ohgaki H;Rakha EA;Reed NS;Rous BA;Sasano H;Scarpa A;Scoazec JY;Travis WD;Tallini G;Trouillas J;van Krieken JH;Cree IA
通讯作者：
Cree IA
影响因子：
9.3
作者：
Duijzentkunst, Daan A. Smit;Kwekkeboom, Dik J.;Bodei, Lisa
通讯作者：
Bodei, Lisa
影响因子：
9.6
作者：
Fink, G;Krelbaum, T;Kramer, MR
通讯作者：
Kramer, MR