Total Synthesis of (-)-Serotobenine
Total Synthesis of (-)-Serotobenine
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DOI：
10.1021/ja807676v
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发表时间：
2008-12-17
影响因子：
15
通讯作者：
Kan, Toshiyuki
中科院分区：
文献类型：
--
作者：
Koizumi, Yasuaki;Kobayashi, Hideki;Kan, Toshiyuki
本课题组开发了通过铑类胡萝卜素介导的分子内C-H插入反应构建光学活性二氢苯并呋喃环，从而实现了(-)-血清苯宁(1)的有效全合成。然后利用光学活性合成1研究了1外消旋化的可能性。
The efficient total synthesis of (-)-serotobenine (1) has been achieved by constructing an optically active dihydrobenzofuran ring via a rhodium carbenoid mediated intramolecular C-H insertion reaction, which was developed by our group. Then the possibility of racemization of 1 was investigated using optically active synthetic 1.