Evolving concepts of chondrogenic differentiation: history, state-of-the-art and future perspectives.
Evolving concepts of chondrogenic differentiation: history, state-of-the-art and future perspectives.
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DOI：
10.22203/ecm.v030a02
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发表时间：
2015-07
影响因子：
3.1
通讯作者：
X. Tang;L. Fan;M. Pei;L. Zeng;Z. Ge
中科院分区：
文献类型：
--
作者：
X. Tang;L. Fan;M. Pei;L. Zeng;Z. Ge
作为一种细胞来源，多能间充质基质细胞或间充质干细胞(MSCs)是一种很有前途的软骨分化和软骨再生的候选细胞。从以往的文献中得知，MSCs向软骨细胞分化必然导致肥大和随后的软骨内成骨。在这篇综述中，我们回顾了目前已建立的软骨分化方案的历史，并阐述了软骨分化介质中个别成分的作用。我们还总结了物理、化学和生物因素的影响，并提出了通过细胞分化和软骨形成的时空融合将MSCs分化为具有同质成熟表型的关节软骨细胞的潜在策略。
As a cell source, multipotent mesenchymal stromal cells or mesenchymal stem cells (MSCs) are promising candidates for chondrogenic differentiation and subsequent cartilage regeneration. From previous literature, it is known that chondrogenic differentiation of MSCs inevitably leads to hypertrophy and subsequent endochondral ossification. In this review, we examine the history of currently established protocols of chondrogenic differentiation and elaborate on the roles of individual components of chondrogenic differentiation medium. We also summarise the effects of physical, chemical and biological factors involved, and propose potential strategies to differentiate MSCs into articular chondrocytes with homogenous mature phenotypes through spatial-temporal incorporation of cell differentiation and chondrogenesis.