ESTIMATION OF BODY-FAT AND LEAN TISSUE DISTRIBUTION BY DUAL-ENERGY X-RAY ABSORPTIOMETRY AND ABDOMINAL BODY-FAT EVALUATION BY COMPUTED-TOMOGRAPHY IN CUSHINGS-DISEASE
ESTIMATION OF BODY-FAT AND LEAN TISSUE DISTRIBUTION BY DUAL-ENERGY X-RAY ABSORPTIOMETRY AND ABDOMINAL BODY-FAT EVALUATION BY COMPUTED-TOMOGRAPHY IN CUSHINGS-DISEASE
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DOI：
10.1210/jc.80.9.2791
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发表时间：
1995-09-01
影响因子：
5.8
通讯作者：
LIBERMAN, B
中科院分区：
文献类型：
--
作者：
WAJCHENBERG, BL;BOSCO, A;LIBERMAN, B
本文对库欣病患者进行了双能X线骨密度仪测定的身体成分和CT扫描测定的腹部内脏脂肪成分，并与相同人体测量学参数的肥胖妇女和非肥胖妇女进行了比较。与肥胖患者相比，库欣患者的全身脂肪或躯干区域(Android)成分没有增加，但腹内脂肪面积更高。与肥胖受试者相比，库欣患者的总瘦组织质量略有下降，这是由于腿部和手臂的肌肉显著减少；手臂中脂肪和瘦组织质量的减少是皮质醇增多症最显著的发现。库欣患者的身体矿物质和骨钙含量与肥胖对照组相比略有下降。因此，虽然肥胖受试者比正常体重的受试者有更多的脂肪、瘦肉组织和矿物质块，但库欣患者的总脂肪质量及其成分(除手臂外)与肥胖者相同，呈现出与非肥胖者相似的总瘦肉组织和部分，包括身体矿物质和骨钙含量，这与非肥胖者相似，原因是蛋白质库耗尽，如皮质醇增多症所见。
Body composition determined by dual energy x-ray absorptiometry and the abdominal visceral fat component determined by computed tomographic scanning were examined in women with Cushing's disease and compared with those in obese women with the same anthropometric parameters and those in nonobese women. Patients with Cushing's had no increase in total body fat or the trunk region (android) component, but had a higher intraabdominal fat area compared to the obese subjects. The total lean tissue mass was slightly reduced in Cushing's compared to that in the obese subjects due to a significant decrease in the muscle of the legs and arms; the reduced amounts of fat and lean tissue masses in the arms were the most significant findings in hypercortisolism.The body mineral and bone calcium contents were slightly reduced in Cushing's compared to those in the obese controls. Thus, although obese subjects had more fat and lean tissue and mineral masses than their normal weight counterparts, the Cushing's patients, with the same total fat mass and its components (except in the arms) as obese individuals, present total lean tissue and fractions, including body mineral and bone calcium contents, similar to those in nonobese subjects due to the depletion of the protein depots, as seen in hypercortisolism.