Unprecedented Molecular Architectures by the Controlled Self-Assembly of a β-Peptide Foldamer
Unprecedented Molecular Architectures by the Controlled Self-Assembly of a β-Peptide Foldamer
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DOI：
10.1002/anie.201003302
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发表时间：
2010-01-01
影响因子：
16.6
通讯作者：
Lee, Hee-Seung
中科院分区：
文献类型：
--
作者：
Kwon, Sunbum;Jeon, Aram;Lee, Hee-Seung
在过去的几十年中，已经研究了几种类型的基于肽的支架，从简单的芳香族二肽到小的蛋白质片段，以了解潜在的机制和模拟来创建人工纳米/微结构。然而，在肽支架中仍然报道了有限数量的设计原则，允许良好定义的自组装结构形成，这可能是由于天然肽固有的大构象灵活性。在这篇演讲中，我们报告了第一个高度均匀的例子，定义明确的和有限的架构的肽自组装。
During past decades, several types of peptide-based scaffolds, ranging from simple aromatic dipeptide to small protein fragments, have been studied to understand the underlying mechanism and mimic to create artificial nano/microstructures. However, a limited number of design principles have still been reported in peptidic scaffolds allowing well-defined self-assembled structure formation, presumably due to the intrinsic large conformational flexibility of natural peptides. In this presentation, we report the first example of highly homogeneous, well-defined and finite architectures by the-peptide self-assembly.