Revisiting the washout period in the incident user study design: why 6-12 months may not be sufficient
Revisiting the washout period in the incident user study design: why 6-12 months may not be sufficient
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DOI：
10.2217/cer.14.53
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发表时间：
2015-01-01
影响因子：
2.1
通讯作者：
Farley, Joel F.
中科院分区：
文献类型：
--
作者：
Roberts, Andrew W.;Dusetzina, Stacie B.;Farley, Joel F.
目的：本研究的目的是描述洗脱期持续时间如何影响回顾性事件用户队列的规模和准确性。材料和方法：使用2007年至2010年的MarketScan商业声明数据，包括2010年具有抗高血压、抗糖尿病或抗抑郁声明的成年人。创建了使用3个月、6个月、12个月、24个月和36个月冲刷的事件用户队列，并描述了样本量和事件用户错误分类的变化。结果与结论：6个月和12个月的冲刷分别排除了75%和85%的样本。6个月洗脱期队列中有一半的受试者实际上是普遍使用者，12个月洗脱期导致30%的错误分类。使用6-12个月的常见洗脱期可能不足以解决大型商业索赔数据库中普遍存在的用户偏倚。
Aims: The purpose of this study was to describe how washout period duration affects the size and accuracy of retrospective incident user cohorts. Materials & methods: MarketScan commercial claims data from 2007 to 2010 were used and included adults with an antihyperlipidemic, antidiabetic or antidepressant claim in 2010. Incident user cohorts using 3-, 6-, 12-, 24- and 36-month washouts were created and changes in sample size and incident user misclassification were described. Results & conclusion: The 6- and 12-month washouts excluded 75 and 85% of the samples, respectively. Half of subjects in the 6-month washout cohorts were actually prevalent users, and the 12-month washout period resulted in 30% misclassified. Using common washout periods of 6-12 months may insufficiently address prevalent user bias in large commercial claims databases.