Partially Reversible Cortical Metabolic Dysfunction in Familial Hemiplegic Migraine With Prolonged Aura
Partially Reversible Cortical Metabolic Dysfunction in Familial Hemiplegic Migraine With Prolonged Aura
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DOI：
10.1111/j.1526-4610.2010.01634.x
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发表时间：
2010-05-01
期刊：
影响因子：
5
通讯作者：
Weiller, Pierre-Jean
中科院分区：
文献类型：
--
作者：
Guedj, Eric;Belenotti, Pauline;Weiller, Pierre-Jean
我们报告了一个23岁的女性家族性偏瘫性偏头痛（FHM）的ATP 1A2基因突变引起的SPECT和PET体素为基础的脑血流和葡萄糖代谢率的分析。与健康受试者相比，PET扫描显示大脑葡萄糖代谢低下，偏瘫的对侧，在发作早期（第1天）的侧裂周围区，没有任何SPECT灌注异常。在第78天，代谢率降低仅部分可逆，此时与剩余的半感觉丧失一致。这些发现为FHM患者的原发性皮质代谢功能障碍提供了进一步的证据。
We report a SPECT and PET voxel-based analysis of cerebral blood flow and metabolic rate for glucose in a 23-year-old woman with familial hemiplegic migraine (FHM) caused by ATP1A2 gene mutation. In comparison with healthy subjects, a PET scan showed brain glucose hypometabolism, controlaterally to the hemiplegia, in the perisylvian area early in the attack (Day 1), without any SPECT perfusion abnormalities. Decrease in metabolic rate was only partially reversible at Day 78, concordant at this time with a remaining hemisensory loss. These findings provide further evidence for a primary cortical metabolic dysfunction in FHM.