Vitamin K-dependent clotting factors are elevated in young adults who have close relatives with ischemic heart disease.
Vitamin K-dependent clotting factors are elevated in young adults who have close relatives with ischemic heart disease.
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发表时间：
1993-12
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影响因子：
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通讯作者：
P. Burns;C. Hoffman;J. Katz;R. Miller;W. Lawson;M. Hultin
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作者：
P. Burns;C. Hoffman;J. Katz;R. Miller;W. Lawson;M. Hultin
VII因子的增加被认为是缺血性心脏病的危险因素。本研究的目的是检验这一假设，即增加因子VII是一个普遍增加维生素K依赖性凝血因子的一部分。最初，在两组没有症状的年轻受试者中进行了因子VII抗原和凝血酶原活性的前瞻性分析，这些受试者基于一级亲属中早发性心脏病的病史（或缺乏病史）而在缺血性心脏病的风险方面存在差异。与低风险组相比，高风险组受试者的凝血酶原活动度和因子VII抗原在统计学上显著增加。在第二组受试者中，还进行了因子IX和X活性测定，发现所有四种维生素K依赖性凝血因子在高风险受试者中显著高于低风险受试者。本研究的第二个目的是探索因子VII与胆固醇和甘油三酯之间的相关性是否可能是由于因子VII与载脂蛋白B的结合。尽管在我们的高危组受试者中发现因子VII抗原与载脂蛋白B显著相关（rho = 0.523，p < 0.025），但因子VII与甘油三酯之间的相关性（rho = 0.641，p < 0.005）在统计学上甚至更强，表明因子VII与极低密度脂蛋白在体内可能相互作用。（250字处删节）
An increase in factor VII was found to be a risk factor for ischemic heart disease. The present study was designed to test the hypothesis that this increase in factor VII is part of a general increase in vitamin K-dependent clotting factors. Initially, a prospective analysis of factor VII antigen and prothrombin activity was performed in two groups of young subjects without symptoms who differed in their risk of ischemic heart disease based on a history (or lack thereof) of premature heart disease in a first-degree relative. A statistically significant increase in prothrombin activity and factor VII antigen was found in the high-risk group of subjects when compared with the low-risk group. In a second series of subjects, factor IX and X activity assays were also performed, and all four of the vitamin K-dependent clotting factors were found to be significantly higher in high-risk subjects when compared with low-risk subjects. A second goal of the study was to explore whether correlations between factor VII and cholesterol and triglycerides might be due to binding of factor VII with apolipoprotein B. Although a significant correlation of factor VII antigen with apolipoprotein B (rho = 0.523, p < 0.025) was found in our high-risk group of subjects, the correlation between factor VII and triglycerides (rho = 0.641, p < 0.005) was even stronger statistically, suggesting a probable interaction of factor VII with very-low-density lipoproteins in vivo.(ABSTRACT TRUNCATED AT 250 WORDS)