Deciphering Clinicoradiologic Phenotype for Thymidylate Synthase Expression Status in Patients with Advanced Lung Adenocarcinoma Using a Radiomics Approach.
Deciphering Clinicoradiologic Phenotype for Thymidylate Synthase Expression Status in Patients with Advanced Lung Adenocarcinoma Using a Radiomics Approach.
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DOI：
10.1038/s41598-018-27273-9
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发表时间：
2018-06-12
影响因子：
4.6
通讯作者：
Ahn MJ
中科院分区：
文献类型：
--
作者：
Lee SW;Park H;Lee HY;Sohn I;Lee SH;Kang J;Sun JM;Ahn MJ
我们的目的是确定晚期非鳞状非小细胞肺癌患者胸苷酸合酶(TS)表达状态的预测性临床放射学特征。我们回顾了169例患者的临床放射学特征，分为TS阴性组(n = 84)和TS阳性组(n = 85)，包括原始CT和正电子发射计算机断层扫描的肺原发灶和转移灶的定量CT影像特征。包括年龄和吸烟史在内的临床因素与TS和放射学特征显著相关。与仅基于临床特征的模型相比，添加原发肺部病变的成像特征时，预测TS表达状态的性能略高，但没有统计学意义(交叉验证的AUC = 分别为0.619和0.581的10倍；P = 0.425)。与包含转移灶相比，只有肺原发灶的临床放射学参数的预测性能略有提高，但没有统计学意义(10倍交叉验证AUC = 分别为0.619和0.554；P = 0.203)。与TS阳性组相比，TS阴性组总生存期延长(P = 0.001)。TS阴性是一个潜在的预后生物标志物，我们的研究表明，尽管CT放射学特征有可能预测TS的表达状态，但临床意义尚不确定。在预测TS阴性方面，将放射学特征添加到临床因素中并没有显示出显著的改善。
We aimed to identify predictive clinicoradiologic characteristics of thymidylate synthase (TS) expression status in advanced non-squamous non-small cell lung cancer patients. We reviewed clinicoradiologic features of 169 patients stratified into TS-negative (n = 84) and TS-positive (n = 85) groups, including quantitative CT radiomic features of both primary lung and metastatic lesions from initial CT and PET. Clinical factors including age and smoking history were significantly associated with TS as well as radiomic features. The predictive performance for dichotomizing TS expression status was slightly higher when imaging features of primary lung lesions were added compared to the model based solely on the clinical features, but without statistical significance (10-fold cross-validated AUC = 0.619 and 0.581, respectively; P = 0.425). The predictive performance of clinicoradiologic parameters slightly increased with primary lung lesions only compared to the inclusion of metastatic lesions, but without statistical significance (10-fold cross-validated AUC = 0.619 and 0.554, respectively; P = 0.203). Overall survival was prolonged in the TS-negative group compared to the TS-positive group (P = 0.001). TS-negativity is a potential prognostic biomarker, and our study presents that although CT radiomic features have potential for predicting TS expression status, clinical significance is uncertain. The addition of radiomic features to clinical factors did not show significant improvement in predicting TS-negativity.
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影响因子：
8.4
作者：
Eisenhauer, E. A.;Therasse, P.;Verweij, J.
通讯作者：
Verweij, J.
影响因子：
3.7
作者：
Grove O;Berglund AE;Schabath MB;Aerts HJ;Dekker A;Wang H;Velazquez ER;Lambin P;Gu Y;Balagurunathan Y;Eikman E;Gatenby RA;Eschrich S;Gillies RJ
通讯作者：
Gillies RJ
影响因子：
3.3
作者：
Adjei, Alex A
通讯作者：
Adjei, Alex A
影响因子：
5.1
作者：
Genuer, Robin;Poggi, Jean-Michel;Tuleau-Malot, Christine
通讯作者：
Tuleau-Malot, Christine
DOI：
10.1007/bfb0029236
发表时间：
1997-01-01
期刊：
CVRMED-MRCAS'97
影响因子：
--
作者：
BroNielsen, M
通讯作者：
BroNielsen, M