Transient cerebral ischemia and brain prostaglandins.
Transient cerebral ischemia and brain prostaglandins.
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短暂性脑缺血和脑前列腺素。
DOI：
10.1016/0006-291x(79)91796-0
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发表时间：
1979
影响因子：
3.1
通讯作者：
Lawrence Levine
中科院分区：
文献类型：
--
作者：
R. Gaudet;Lawrence Levine
测定沙鼠脑缺血2小时及短暂性缺血后再灌注时的前列腺素水平。pgf2 α及其代谢物（13,14-二氢-15-酮- pgf2 α）水平低，缺血时无变化。然而，PGF2α、13,14-二氢-15-酮-PGF2α、PGE2和血栓素b2在短暂缺血后的再灌注中升高。吲哚美辛或阿司匹林抑制了这种增加。用吲哚美辛预处理的动物比未处理的动物恢复更快，再灌注时更活跃。
Prostaglandin levels were measured in gerbil brain during cerebral ischemia for up to 2 hours, and during reperfusion after various periods of transient ischemia. The levels of PGF2αand its metabolite (13,14-dihydro-15-keto-PGF2α) were low and did not change during ischemia. However, PGF2α, 13,14-dihydro-15-keto-PGF2α, PGE2, and thromboxane B2increased during reperfusion after brief episodes of ischemia. Indomethacin or aspirin inhibited this increase. Animals pretreated with indomethacin recovered more rapidly and were more active during reperfusion than those without treatment.