Disparate letter and semantic category fluency deficits in autopsy-confirmed frontotemporal dementia and Alzheimer's disease
Disparate letter and semantic category fluency deficits in autopsy-confirmed frontotemporal dementia and Alzheimer's disease
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DOI：
10.1037/0894-4105.21.1.20
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发表时间：
2007-01-01
期刊：
影响因子：
2.4
通讯作者：
Galasko, Douglas
中科院分区：
文献类型：
--
作者：
Rascovsky, Katya;Salmon, David P.;Galasko, Douglas
对尸检证实的额颞叶痴呆（FTD; n=16）和阿尔茨海默病（AD; n=32）患者的首字母和语义类别流畅性任务进行了比较。尽管在年龄、教育和痴呆严重程度上匹配，但FTD患者的总体表现较差，字母和语义类别流畅性受损相似，而AD患者的语义类别流畅性受损大于字母流畅性。字母和语义类别流畅性（语义指数）之间的差距的措施是有效的区分FTD从AD患者，这种差距随着痴呆的严重程度增加。这些独特的字母和语义类别流畅性缺陷的模式可能是指在相对贡献的额叶介导的检索赤字和颞叶介导的语义赤字在FTD和AD的差异。
Patients with autopsy-confirmed frontotemporal dementia (FTD; n=16) and Alzheimer's disease (AD; n=32) were compared on first-letter and semantic category fluency tasks. Despite being matched on age, education, and dementia severity, FTD patients performed worse overall and showed similar impairment in letter and semantic category fluency, whereas AD patients showed greater impairment in semantic category than letter fluency. A measure of the disparity between letter and semantic category fluency (the semantic index) was effective in differentiating FTD from AD patients, and this disparity increased with increasing severity of dementia. These unique patterns of letter and semantic category fluency deficits may be indicative of differences in the relative contribution of frontal-lobe-mediated retrieval deficits and temporal-lobe-mediated semantic deficits in FTD and AD.