RATIONALE DEVELOPED BY ENVIRONMENTAL-PROTECTION AGENCY FOR ASSESSMENT OF CARCINOGENIC RISKS
RATIONALE DEVELOPED BY ENVIRONMENTAL-PROTECTION AGENCY FOR ASSESSMENT OF CARCINOGENIC RISKS
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DOI：
10.1093/jnci/58.5.1537
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发表时间：
1977-01-01
影响因子：
10.3
通讯作者：
ANDERSON, E
中科院分区：
文献类型：
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作者：
ALBERT, RE;TRAIN, RE;ANDERSON, E
环境保护局S《致癌物风险评估暂行指南》的目的是对可疑致癌物的证据进行评估，其中包括对数据质量和充分性的判断，对该制剂是人类致癌物的可能性的判断，以及对如果不采取监管行动可归因于该制剂的癌症负担程度的估计。应尽一切努力将致癌物对环境的污染减少到尽可能低的水平；这一观点源于从动物到人的定性和定量推断的不确定性、缺乏剂量阈值的证据、环境致癌物和辅助因素之间可能存在的广泛相互作用以及人类的广泛易感性。致癌领域的新知识正在发展，环境保护局S的《致癌物质风险评估暂行指南》必须定期修改。
The intent of the Environmental Protection Agency''s "Interim Guideline for Carcinogen Risk Assessment" is to provide an evaluation of the evidence regarding suspect carcinogens that encapsulates judgments on the quality and adequacy of data, the likelihood that the agent is a human carcinogen, and an estimate of the magnitude of the cancer burden that could be ascribed to the agent if no regulatory action were taken. Every effort should be made to reduce environmental contamination by carcinogens to the lowest possible level; this view stems from uncertainties about qualitative and quantitative extrapolations from animals to man, the lack of evidence for a dose threshold, the great range of possible interactions among environmental carcinogens and cofactors, and the broad spectrum of human susceptibility. New knowledge in the field of carcinogenesis is developing, and modifications of the Environmental Protection Agency''s "Interim Guideline for Carcinogen Risk Assessment" must be made periodically.