Oestrogen receptor beta is involved in the actions of oestrogens in the brain for affective behaviour, but not trophic effects in peripheral tissues.
Oestrogen receptor beta is involved in the actions of oestrogens in the brain for affective behaviour, but not trophic effects in peripheral tissues.
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DOI：
10.1111/j.1365-2826.2009.01945.x
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发表时间：
2010-02
影响因子：
3.2
通讯作者：
Walf AA
中科院分区：
文献类型：
--
作者：
Walf AA
类固醇，17β-雌二醇(E2)，在整个生命周期中具有普遍的心理和生理影响。一个问题是，在中枢神经系统(CNS)和外周是否存在不同的雌激素受体(ER)介导的这些效应机制。这篇综述将集中于使用整个动物模型(即雌性大鼠和小鼠)来研究雌激素在中枢和外周的相对作用和机制的研究结果。通过使用这种方法，已经有可能区分E2‘S增强通过海马体介导的行为过程的作用，如情感行为，以及促进肿瘤发生和子宫生长的营养作用。使用药物操作和基因敲除小鼠的研究表明，E2对海马区功能的有益影响而不是体内的增殖效应的可能机制涉及ERβ的作用、细胞周期/分裂的变化(例如细胞周期蛋白D1)和/或组蛋白修饰。因此，有可能区分雌激素通过ERβ的有益作用，特别是在中枢神经系统中，与对外周E2敏感组织的负面增殖作用不同。
The steroid, 17β-oestradiol (E2) has pervasive psychological and physical effects throughout the lifespan. A question is whether there are divergent oestrogen receptor (ER)-mediated mechanisms for these effects in the central nervous system (CNS) and periphery. This review will focus on results of studies using a whole animal model (i.e. female rats and mice) to investigate the relative effects and mechanisms of oestrogens in the CNS and the periphery. By using this approach, it has been possible to differentiate E2’s enhancing effects on behavioural processes mediated by the hippocampus, such as affective behaviour, and trophic effects to increase tumourigenesis and uterine growth. Studies using pharmacological manipulations and knockout mice are reviewed that suggest that a likely mechanism underlying the beneficial effects of E2 for hippocampal function, but not proliferative effects in the body, involve actions at ERβ, changes in cell cycle/division (e.g. cyclin D1), and/or histone modifications. Thus, it may be possible to differentiate the beneficial effects of oestrogens through ERβ, particularly in the CNS, from negative proliferative effects on peripheral, E2-sensitive tissues.
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