EZH2 and STAT6 expression profiles are correlated with colorectal cancer stage and prognosis
EZH2 and STAT6 expression profiles are correlated with colorectal cancer stage and prognosis
复制标题
EZH2和STAT6表达谱与结直肠癌分期和预后相关
DOI：
10.3748/wjg.v16.i19.2421
复制
发表时间：
2010-05-21
影响因子：
4.3
通讯作者：
Wang, Shan
中科院分区：
文献类型：
--
作者：
Wang, Cheng-Gang;Ye, Ying-Jiang;Wang, Shan
目的：目的：探讨zeste同源物增强子2（enhancer of zeste homologue 2，EZH 2）和STAT 6在结直肠癌临床分期和预后评估中的作用。方法：采用免疫组化方法检测2002 ~ 2004年119例结直肠癌患者癌组织和癌旁非肿瘤组织中EZH 2和STAT 6的表达。EZH 2和STAT 6在结直肠癌组织中的阳性表达率分别为69.7%（83/119）和60.5%（72/119），与癌旁组织相比差异有统计学意义（P < 0.05）。在所有结直肠癌病例中，EZH 2阳性或STAT 6阳性表达的患者的生存率低于EZH 2阴性或STAT 6阴性表达的患者（分别为P = 0.002和P = 0.005）。EZH 2和STAT 6在临床TNM分期高的结直肠癌组织中共表达显著增高（P = 0.001），STAT 6的表达与结直肠癌的淋巴结转移和远处转移有关（P = 0.001和P = 0.016）。多因素分析显示EZH 2表达是大肠癌独立的预后指标（P = 0.039）。结论：EZH 2和STAT 6表达对大肠癌的临床分期和预后判断有重要价值。(C)2010年百世登。All rights reserved.
AIM: To investigate the role of enhancer of zeste homologue 2 (EZH2) and STAT6 immunohistochemistry in the evaluation of clinical stages and prognosis of colorectal cancer (CRC).METHODS: The expression patterns were examined by immunohistochemistry in both tumor and adjacent non-neoplastic tissues of 119 CRC patients who underwent operation during the time period from 2002 to 2004.RESULTS: The positive rates of EZH2 and STAT6 in CRC cases were 69.7% (83 of 119) and 60.5% (72 of 119), respectively, and there was significant difference when compared with tumor adjacent non-neoplastic tissues (P < 0.05). In all CRC cases, patients with EZH2-positive, or STAT6-positive expression had lower survival rates than those with EZH2-negative or STAT6-negative expression (P = 0.002 and P = 0.005, respectively). Co-expression of EZH2 and STAT6 showed significantly higher levels in CRC cases of high clinical TNM stages (P = 0.001), and the expression of STAT6 was also correlated with lymph node metastasis and distant metastasis (P = 0.001 and P = 0.016, respectively). Multivariate analysis revealed that EZH2 expression was an independent prognostic indicator of CRC (P = 0.039).CONCLUSION: EZH2 and STAT6 expressions have significant values in distinguishing clinical stages of CRC and predicting the prognosis of the patients. (C) 2010 Baishideng. All rights reserved.