Murine models of human wound healing.
Murine models of human wound healing.
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DOI：
10.1007/978-1-62703-505-7_15
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Gurtner GC
中科院分区：
文献类型：
--
作者：
Chen JS;Longaker MT;Gurtner GC
体内伤口愈合实验仍然是研究人体伤口愈合的最具预测性的模型，它可以准确地描述完整的伤口愈合环境，包括各种细胞类型、环境线索和旁分泌相互作用。小动物经济，易于维护，并且允许研究人员利用已经开发的许多转基因菌株来研究涉及伤口愈合和再生的特定机制。在这里，我们描述了再现人类伤口愈合过程的三种可重复的小鼠伤口愈合模型。
In vivo wound healing experiments remain the most predictive models for studying human wound healing, allowing an accurate representation of the complete wound healing environment including various cell types, environmental cues, and paracrine interactions. Small animals are economical, easy to maintain, and allow researchers to take advantage of the numerous transgenic strains that have been developed to investigate the specific mechanisms involved in wound healing and regeneration. Here we describe three reproducible murine wound healing models that recapitulate the human wound healing process.