Interstitial Fluidopathy of the Central Nervous System: An Umbrella Term for Disorders with Impaired Neurofluid Dynamics
Interstitial Fluidopathy of the Central Nervous System: An Umbrella Term for Disorders with Impaired Neurofluid Dynamics
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DOI：
10.2463/mrms.rev.2022-0012
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发表时间：
2022-11
影响因子：
3
通讯作者：
T. Taoka;Rintaro Ito;Rei Nakamichi;T. Nakane;H. Kawai;S. Naganawa
中科院分区：
文献类型：
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作者：
T. Taoka;Rintaro Ito;Rei Nakamichi;T. Nakane;H. Kawai;S. Naganawa
自从提出类淋巴系统假说以来，人们对间质流体动力学的兴趣有所增加。间质液的异常动态已被指出是各种病理状态的重要因素。在本文中，我们提出中枢神经系统间质性液体病的概念，即一种疾病或病症，其中异常的间质液体动力学是病理病症发展的重要因素之一。我们讨论各种疾病中间质性液体病变的各个方面，包括阿尔茨海默病、帕金森病、正常压力脑积水和脑小血管疾病。我们还讨论了一种使用 MR 扩散图像的“沿血管周围空间的扩散张量图像分析”的方法，该方法用于评估间质液病变的程度或类淋巴系统的活动。
Interest in interstitial fluid dynamics has increased since the proposal of the glymphatic system hypothesis. Abnormal dynamics of the interstitial fluid have been pointed out to be an important factor in various pathological statuses. In this article, we propose the concept of central nervous system interstitial fluidopathy as a disease or condition in which abnormal interstitial fluid dynamics is one of the important factors for the development of a pathological condition. We discuss the aspects of interstitial fluidopathy in various diseases, including Alzheimer’s disease, Parkinson’s disease, normal pressure hydrocephalus, and cerebral small vessel disease. We also discuss a method called “diffusion tensor image analysis along the perivascular space” using MR diffusion images, which is used to evaluate the degree of interstitial fluidopathy or the activity of the glymphatic system.