Effect of levothyroxine on prolonged nocturnal sleep time and excessive daytime somnolence in patients with idiopathic hypersomnia
Effect of levothyroxine on prolonged nocturnal sleep time and excessive daytime somnolence in patients with idiopathic hypersomnia
复制标题
左旋甲状腺素对特发性嗜睡症患者夜间睡眠时间延长和白天过度嗜睡的影响
DOI：
10.1016/j.sleep.2011.02.004
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发表时间：
2011
期刊：
影响因子：
4.8
通讯作者：
Yu Nakamura
中科院分区：
文献类型：
--
作者：
Hideto Shinno;Ichiro Ishikawa;Mami Yamanaka;Ai Usui;Sonoko Danjo;Yasushi Inami;Jun Horiguchi;Yu Nakamura
本研究的目的是研究左旋甲状腺素，甲状腺激素，延长夜间睡眠和过度白天嗜睡（EDS）的患者与特发性hypersomnia.MethodsIn一项前瞻性的，开放标签的研究，9例患者参加。所有受试者均符合国际睡眠障碍分类第2版（ICSD-2）定义的特发性睡眠过度伴长睡眠时间的标准。排除了患有睡眠呼吸暂停综合征、肥胖或甲状腺功能减退症的受试者。睡眠结构和主观白天嗜睡分别采用多导睡眠图（PSG）和埃普沃思嗜睡量表（ESS）进行评估。基线检查后，每天口服左旋甲状腺素（25 μg/天）。比较治疗前、后（2、4、8周）的平均总睡眠时间、ESS评分。基线时，平均总睡眠时间（小时）和ESS评分分别为12.9 ± 0.3和17.8 ± 1.4。治疗后4周和8周的平均总睡眠时间分别为9.1 ± 0.7和8.5 ± 1.0 h。治疗第4周和第8周的平均ESS评分分别为8.8 ± 2.3和7.4 ± 2.8。1例患者在第2周因效果不佳而退出。结论左旋甲状腺素治疗4周以上，睡眠时间延长，EDS改善。左旋甲状腺素对嗜睡有效，耐受性良好。
ObjectiveThis study aims to examine the effect of levothyroxine, a thyroid hormone, on a prolonged nocturnal sleep and excessive daytime somnolence (EDS) in patients with idiopathic hypersomnia.MethodsIn a prospective, open-label study, nine patients were enrolled. All subjects met criteria for idiopathic hypersomnia with long sleep time defined by the International Classification of Sleep Disorders, 2nd edition (ICSD-2). Subjects with sleep apnea syndrome, obesity or hypothyroidism were excluded. Sleep architecture and subjective daytime somnolence were estimated by polysomnography (PSG) and Epworth Sleepiness Scale (ESS), respectively. After baseline examinations, levothyroxine (25 μg/day) was orally administered every day. Mean total sleep time, ESS score at baseline were compared with those after treatment (2, 4 and 8 weeks).ResultsMean age of participants was 23.8 ± 13.7 years old. At baseline, mean total sleep time (hours) and ESS score were 12.9 ± 0.3 and 17.8 ± 1.4, respectively. Mean total sleep times after treatment were 9.1 ± 0.7 and 8.5 ± 1.0 h at 4 and 8 treatment weeks, respectively. Mean ESS scores were 8.8 ± 2.3 and 7.4 ± 2.8 at 4 and 8 treatment weeks, respectively. One patient dropped out at the 2nd week due to poor effect. No adverse effects were noted.ConclusionsAfter treatment with levothyroxine for over 4 weeks, prolonged sleep time and EDS were improved. Levothyroxine was effective for hypersomnia and well tolerated.