Large molecular form of serum HBeAg in chronic hepatitis B virus infection: Relation to liver cell damage
Large molecular form of serum HBeAg in chronic hepatitis B virus infection: Relation to liver cell damage
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慢性乙型肝炎病毒感染中血清大分子HBeAg：与肝细胞损伤的关系
DOI：
10.1002/hep.1840130609
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发表时间：
1991
期刊：
影响因子：
13.5
通讯作者：
K. Hino
中科院分区：
文献类型：
--
作者：
K. Kurai;S. Iino;K. Kurokawa;K. Shimoda;K. Hino
我们用琼脂糖凝胶电泳将循环中的HBeAg分为小分子和大分子两种形式，并分析了这两种形式与慢性B型肝炎其他临床特征，特别是肝细胞损害的关系。9例肝组织学检查正常或非特异性反应性肝炎患者中，大HBeAg占血清HBeAg的7.3% ± 3.4%，32例慢性迁延性肝炎患者中为38.0% ± 27.8%，21例慢性活动性肝炎患者中为65.6% ± 23.3%（P <0.01）。转氨酶升高的高度与大HBeAg的百分比呈正相关。3例从肝组织学正常或非特异性反应性肝炎进展为慢性活动性肝炎的患者，其大HBeAg百分比显著增加。血清中大HBeAg的存在与肝炎的严重程度相关，这一发现提示HBeAg可能在决定慢性B型肝炎的肝损伤程度中起重要作用。（《肝脏学》1991年; 13：1057 - 1060）
We have separated circulating HBeAg into small and large molecular forms by agarose gel electrophoresis and analyzed the relationship between the two forms and other clinical features of chronic hepatitis B, especially in regard to liver cell damage. The large HBeAg accounted for 7.3% ± 3.4% of serum HBeAg in 9 subjects with normal liver histological findings or nonspecific reactive hepatitis, 38.0% ± 27.8% in 32 patients with chronic persistent hepatitis and 65.6% ± 23.3% in 21 patients with chronic active hepatitis (p < 0.01). A positive correlation was seen between the height of aminotransferase elevations and the percentage of large HBeAg. Three patients who progressed from histologically normal liver or nonspecific reactive hepatitis to chronic active hepatitis had dramatic increases in the percentage of large HBeAg. The finding that the presence of large HBeAg in serum correlated with the severity of hepatitis suggests that HBeAg may play an important role in determining the degree of liver injury in chronic hepatitis B. (HEPATOLOGY 1991;13:1057–1060.)