Effect of halothane anesthesia on muscle, liver, thyroid, and adrenal-function tests in man.
Effect of halothane anesthesia on muscle, liver, thyroid, and adrenal-function tests in man.
复制标题
氟烷麻醉对人体肌肉、肝脏、甲状腺和肾上腺功能测试的影响。
DOI：
10.1093/clinchem/22.2.217
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发表时间：
1976
影响因子：
9.3
通讯作者：
R. Ebersole
中科院分区：
文献类型：
--
作者：
R. Johnstone;E. Kennell;W. Brummund;L. Shaw;R. Ebersole
七名健康男性志愿者在未进行手术的情况下接受了 6.6 +/- 1.3 (SD)% 小时的氟烷氧气麻醉。麻醉后血清胆红素、丙氨酸转氨酶和天冬氨酸转氨酶显着升高，这可能表明存在亚临床肝细胞损伤。 6 名受试者的骨骼肌来源肌酸激酶增加至 90 U/L 以上，表明存在亚临床肌细胞损伤。麻醉后皮质醇、三碘甲状腺原氨酸摄取、甲状腺素和游离甲状腺素指数立即显着增加。麻醉后第二天，血清溴化物浓度增加了五倍，第九天仍然增加了四倍。麻醉后 6 小时口腔温度升高 0.7 摄氏度，可能是由于甲状腺素活性增加。乳酸脱氢酶、羟基丁酸脱氢酶和γ-谷氨酰转移酶活性没有显着变化。在本研究过程中施用的药物不会对所使用的任何测试方法产生化学干扰。
Seven healthy men volunteers received 6.6 +/- 1.3 (SD) percent-hours of halothane oxygen anesthesia without surgery. Serum bilirubin, alanine aminotransferase, and aspartate aminotransferase significantly increased after anesthesia, which may indicate subclinical liver-cell damage. Creatine kinase of skeletal muscle origin increased above 90 U/liter in six subjects, indicating subclinical muscle-cell damage. Cortisol, triiodothyronine uptake, thyroxine, and free thyroxine index increased significantly immediately after anesthesia. Serum bromide concentrations had increased by fivefold on the second day after anesthesia, and on the ninth day was still elevated fourfold. Oral temperatures increased 0.7 degrees C 6 h post-anesthesia, possibly because of increased thyroxine activity. Lactate dehydrogenase, hydroxybutyrate dehydrogenase and gamma-glutamyltransferase activities did not change significantly. No drugs administered during the course of this study chemically interfered with any of the test methods used.