Magnetoencephalography Imaging Reveals Abnormal Information Flow in Temporal Lobe Epilepsy.
Magnetoencephalography Imaging Reveals Abnormal Information Flow in Temporal Lobe Epilepsy.
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DOI：
10.1089/brain.2020.0989
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发表时间：
2022-05
影响因子：
3.4
通讯作者：
中科院分区：
文献类型：
--
作者：
广泛的网络中断被认为是难治性颞叶癫痫(TLE)患者预后的重要预测因素。大多数关于癫痫功能性网络中断的研究主要集中在网络连接强度的对称双向度量上。然而，对癫痫网络功能障碍影响的更完整的描述需要对潜在的更敏感的信息流的方向性度量进行调查。这项研究描述了一种全脑脑磁图成像方法来检查TLE患者和健康对照组(HCS)的静息状态定向信息流网络，该网络由相转移熵(PTE)量化。本研究还探讨了PTE与癫痫综合征临床特征的关系。信息流的缺陷是阿尔法频段特有的。在α波段，当HCS表现出明显的从后到前的信息流动时，在TLE患者中，这种区域信息流出和流入的模式在额区和枕区发生了显著的改变。选定脑区阿尔法频段内信息流的变化与发作间期棘波频率和癫痫持续时间相关。信息流受损是网络功能障碍的一个重要方面，与TLE的病理生理机制有关。要完整描述颞叶癫痫(TLE)的网络功能障碍，需要研究大脑网络中的信息流。在这项全脑脑磁图成像研究中，我们使用信息论测量方法--相转移熵，检测了TLE患者信息流的强度和方向性。异常信息流被记录在案，并与某些脑区癫痫相关的临床措施有关。这里描述的方法可能为研究其他神经和精神疾病的网络功能障碍提供一个有用的框架。
Widespread network disruption has been hypothesized to be an important predictor of outcomes in patients with refractory temporal lobe epilepsy (TLE). Most studies examining functional network disruption in epilepsy have largely focused on the symmetric bidirectional metrics of the strength of network connections. However, a more complete description of network dysfunction impacts in epilepsy requires an investigation of the potentially more sensitive directional metrics of information flow. This study describes a whole-brain magnetoencephalography-imaging approach to examine resting-state directional information flow networks, quantified by phase-transfer entropy (PTE), in patients with TLE compared with healthy controls (HCs). Associations between PTE and clinical characteristics of epilepsy syndrome are also investigated. Deficits of information flow were specific to alpha-band frequencies. In alpha band, while HCs exhibit a clear posterior-to-anterior directionality of information flow, in patients with TLE, this pattern of regional information outflow and inflow was significantly altered in the frontal and occipital regions. The changes in information flow within the alpha band in selected brain regions were correlated with interictal spike frequency and duration of epilepsy. Impaired information flow is an important dimension of network dysfunction associated with the pathophysiological mechanisms of TLE. A complete description of network dysfunction in temporal lobe epilepsy (TLE) requires investigation of the flow of information in brain networks. In this whole-brain magnetoencephalography imaging study, using an information theory measure, phase-transfer entropy, we examine the strength and directionality of information flow in patients with TLE. Abnormal information flow was documented and was associated with clinical measures related to epilepsy in certain brain regions. The approach described here may provide a useful framework to investigate network dysfunction in other neurological and psychiatric disorders.
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DOI：
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影响因子：
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影响因子：
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