Thick Visual Cortex in the Early Blind
Thick Visual Cortex in the Early Blind
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盲人早期视觉皮层较厚
DOI：
10.1523/jneurosci.5451-08.2009
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发表时间：
2009-02-18
影响因子：
5.3
通讯作者：
Jiang, Tianzi
中科院分区：
文献类型：
--
作者：
Jiang, Jiefeng;Zhu, Wanlin;Jiang, Tianzi
我们研究了决定皮质厚度的关键神经发育因素，即突触发生和退化，通过分析早发性和晚发性失明患者的视皮质厚度。早盲组双侧视皮层厚度明显大于晚盲组和正常对照组，但后两组差异不显著。这表明视觉皮质中突触的“修剪”减少，这可能是由于在关键发育时期缺乏视觉体验造成的。这些发现支持了这样的假设，即感觉经验是必要的适当的回归和神经元过程的重塑，突触回归可能是一个主要的决定因素，宏观解剖特征，如皮质厚度。
We investigated the key neurodevelopmental factors that determine cortical thickness, namely synaptogenesis and regression, by analyzing the thickness of the visual cortex in humans with early- and late-onset blindness. The bilateral visual cortices of the early blind were significantly thicker than those of the late blind and the sighted controls, but the latter two groups did not differ significantly. This suggests reduced "pruning" of synapses in the visual cortex, which may be due to a lack of visual experience during a critical developmental period. These findings support the hypothesis that sensory experience is necessary for an appropriate regression and remodeling of neuronal processes and that synaptic regression might be a major determinant of macroscopic anatomical features like cortical thickness.