Interleukin-10 levels in seminal plasma: implications for chronic prostatitis-chronic pelvic pain syndrome.
Interleukin-10 levels in seminal plasma: implications for chronic prostatitis-chronic pelvic pain syndrome.
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DOI：
10.1016/s0022-5347(01)69139-0
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发表时间：
2002-02
期刊：
影响因子：
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通讯作者：
L. Miller;K. A. Fischer;S. Goralnick;M. Litt;J. Burleson;P. Albertsen;D. Kreutzer
中科院分区：
文献类型：
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作者：
L. Miller;K. A. Fischer;S. Goralnick;M. Litt;J. Burleson;P. Albertsen;D. Kreutzer
PurposeChronic prostatitis-chronic pelvic pain syndrome is a disease of unknown pathogenesis. We investigated whether the chronic inflammation and pain experienced by patients may be caused by an imbalance of proinflammatory versus anti-inflammatory cytokines within the prostate, namely interleukin (IL)-8, interferon-γ and IL-2 versus IL-10. We measured these inflammatory cytokines in seminal plasma as a reflection of the prostate environment.Materials and MethodsWe measured levels of IL-8, interferon-γ, IL-2 and IL-10 in the seminal plasma of 31 patients with chronic prostatitis-chronic pelvic pain syndrome and 14 controls using enzyme-linked immunosorbent assay. Results were correlated with health related quality of life, as measured by the Multidimensional Pain Inventory, McGill pain questionnaire and International Prostate Symptom Score.ResultsThe cytokines analyzed were detectable in the seminal plasma of patients with chronic prostatitis-chronic pelvic pain syndrome and controls. Interferon-γ, IL-2 and IL-10 levels were statistically greater in patients. Furthermore, IL-10 levels correlated directly with measures of life interference (r = 0.52, p <0.01) and pain severity (r = 0.53, p <0 0.01), and inversely with spousal support (r = −0.39, p <0.04).ConclusionsOur study suggests that IL-10 may have a role in the pain symptoms experienced by patients with chronic prostatitis-chronic pelvic pain syndrome.
