Photocrosslinkable chitosan as a dressing for wound occlusion and accelerator in healing process
Photocrosslinkable chitosan as a dressing for wound occlusion and accelerator in healing process
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DOI：
10.1016/s0142-9612(01)00189-2
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发表时间：
2002-02-01
期刊：
影响因子：
14
通讯作者：
Kurita, A
中科院分区：
文献类型：
--
作者：
Ishihara, M;Nakanishi, K;Kurita, A
应用紫外光（UV-）照射光交联壳聚糖（Az-CH-LA）水溶液导致不溶。在60 s内，柔性水凝胶类似于软橡胶。壳聚糖水凝胶可在紫外线照射30 s内完全止血，并可将两片小鼠皮肤牢固地粘附在一起。为了评价其对伤口愈合的加速作用，在小鼠背部上制作全厚度皮肤切口，随后将Az-CH-LA水溶液加入到伤口中并用UV光照射90秒。应用壳聚糖水凝胶显著诱导伤口收缩并加速伤口闭合和愈合。组织学检查还证实了在壳聚糖水凝胶处理的伤口中的高级肉芽组织形成和上皮形成。壳聚糖水凝胶由于其加速愈合的能力，被认为是紧急止血情况下伤口闭合和组织粘合的优秀敷料，（C）2001 Elsevier Science Ltd.保留所有权利。
Application of ultraviolet light (UV-) irradiation to a photocrosslinkable chitosan (Az-CH-LA) aqueous solution resulted in an insoluble. flexible hydrogel like soft rubber within 60 s. The chitosan hydrogel could completely stop bleeding from a cut Mouse tail within 30 s of UV-irradiation and could firmly adhere two pieces of sliced skins of mouse to each other. In order to evaluate its accelerating effect on wound healing, full thickness-skin incisions were made on the back of mice and subsequently an Az-CH-LA aqueous solution was added into the wound and irradiated with UV light for 90 s. Application of the chitosan hydrogel significantly induced wound contraction and accelerated wound closure and healing. Histological examinations also have demonstrated an advanced granulation tissue formation and epithelialization in the chitosan hydrogel treated wounds. The chitosan hydrogel due to its accelerating healing ability is considered to become an excellent dressing for wound occlusion and tissue adhesive in urgent hemostasis Situations, (C) 2001 Elsevier Science Ltd. All rights reserved.