Identification and Tissue Distribution of Fucoxanthinol and Amarouciaxanthin A Fatty Acid Esters in Fucoxanthin-fed Mice
Identification and Tissue Distribution of Fucoxanthinol and Amarouciaxanthin A Fatty Acid Esters in Fucoxanthin-fed Mice
复制标题
岩藻黄质喂养小鼠中岩藻黄质醇和 Amarouciaxanthin A 脂肪酸酯的鉴定和组织分布
DOI：
10.1016/j.foodchem.2022.135318
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发表时间：
2023
期刊：
影响因子：
8.8
通讯作者：
Hosokawa Masashi
中科院分区：
文献类型：
--
作者：
Takatani Naoki;Sakimura Kana;Nagata Kodai;Beppu Fumiaki;Yamano Yumiko;Maoka Takashi;Hosokawa Masashi
服用类胡萝卜素脂肪酸酯被认为是水解成其游离形式并被吸收到体内，并且关于类胡萝卜素脂肪酸酯的组织分布的信息有限。岩藻黄素是一种海洋类胡萝卜素，具有多种健康益处，包括抗糖尿病和抗肥胖作用。然而，岩藻黄质在哺乳动物中的代谢仍不清楚。在此，我们研究了岩藻黄质代谢物，岩藻黄醇和amarouciaxanthin A的脂肪酸酯，在雄性C57 BL/6 J小鼠喂食含岩藻黄质的饮食一周的组织。岩藻黄素醇和苦杏仁黄素A-3-酯分别在肝脏和附睾白色脂肪组织中大量蓄积。这些酯在血清和其他组织中检测不到。因此，这表明岩藻黄醇和苦杏仁黄质A在以其游离形式通过身体转运后在肝脏和附睾白色脂肪组织中部分酰化。本研究提出了一种新的类胡萝卜素代谢途径在哺乳动物。
Administered carotenoid fatty acid esters are thought to be hydrolyzed to their free forms and absorbed into the body, and information on the tissue distribution of carotenoid fatty acid esters has been limited. Fucoxanthin, a marine carotenoid, exhibits various health benefits, including anti-diabetic and anti-obesity effects. However, fucoxanthin metabolism in mammals remains unclear. Herein, we investigated the fatty acid esters of fucoxanthin metabolites, fucoxanthinol and amarouciaxanthin A, in the tissues of male C57BL/6J mice fed a fucoxanthin-containing diet for one week. Fucoxanthinol and amarouciaxanthin A-3-esters accumulated abundantly in the liver and epididymal white adipose tissue, respectively. These esters were less detectable in the serum and other tissues. Therefore, it is suggested that fucoxanthinol and amarouciaxanthin A are partially acylated in the liver and epididymal white adipose tissue after being transported through the body as their free forms. This study presents a novel carotenoid metabolic pathway in mammals.