Effect of Risperidone Monotherapy on Dynamic Functional Connectivity of Insular Subdivisions in Treatment-Naive, First-Episode Schizophrenia
Effect of Risperidone Monotherapy on Dynamic Functional Connectivity of Insular Subdivisions in Treatment-Naive, First-Episode Schizophrenia
复制标题
利培酮单一疗法对初治首发精神分裂症岛叶动态功能连接的影响
DOI：
10.1093/schbul/sbz087
复制
发表时间：
2020-05-01
影响因子：
6.6
通讯作者：
Chen, Huafu
中科院分区：
文献类型：
--
作者：
Duan, Xujun;Hu, Maolin;Chen, Huafu
目的：脑皮层由功能多样的亚区组成，每个亚区在精神分裂症的神经病理学中起着不同的作用。当前研究的目的是探讨精神分裂症岛叶分区动态功能连接（dFC）的异常模式以及抗精神病药物对这些连接的影响。研究方法：对42例首发精神分裂症初治患者进行了基于静息态功能磁共振成像（fMRI）的岛叶亚区dFC纵向研究。结果如下：在基线时，与健康对照组相比，患者显示岛叶分区与楔前叶、辅助运动区和颞叶皮质之间的dFC方差降低（变量较少），以及岛叶分区与顶叶皮质之间的dFC方差增加（变量较多）。治疗后，异常连接的dFC方差正常化，伴随着阳性症状的显著改善。结论：我们的研究结果突出了异常模式的波动连接的岛叶细分电路在精神分裂症，并建议这些异常可能会修改后，抗精神病药物治疗。
Objective: The insula consists of functionally diverse subdivisions, and each division plays different roles in schizophrenia neuropathology. The current study aimed to investigate the abnormal patterns of dynamic functional connectivity (dFC) of insular subdivisions in schizophrenia and the effect of antipsychotics on these connections. Methods: Longitudinal study of the dFC of insular subdivisions was conducted in 42 treatment-naive first-episode patients with schizophrenia at baseline and after 8 weeks of risperidone treatment based on resting-state functional magnetic resonance image (fMRI). Results: At baseline, patients showed decreased dFC variance (less variable) between the insular subdivisions and the precuneus, supplementary motor area and temporal cortex, as well as increased dFC variance (more variable) between the insular subdivisions and parietal cortex, compared with healthy controls. After treatment, the dFC variance of the abnormal connections were normalized, which was accompanied by a significant improvement in positive symptoms. Conclusions: Our findings highlighted the abnormal patterns of fluctuating connectivity of insular subdivision circuits in schizophrenia and suggested that these abnormalities may be modified after antipsychotic treatment.