EUROCARE-4. Survival of cancer patients diagnosed in 1995-1999. Results and commentary
EUROCARE-4. Survival of cancer patients diagnosed in 1995-1999. Results and commentary
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DOI：
10.1016/j.ejca.2008.11.018
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发表时间：
2009-04-01
影响因子：
8.4
通讯作者：
Capocaccia, Riccardo
中科院分区：
文献类型：
--
作者：
Sant, Milena;Allemani, Claudia;Capocaccia, Riccardo
EUROCARE-4分析了来自23个欧洲国家82个癌症登记处的约300万例成人癌症病例，这些病例在1995-1999年诊断并随访至2003年12月。对于每个癌症部位，按年龄和性别列出了1年、3年和5年时观察到的平均欧洲面积加权生存率和相对生存率。还显示了国家特异性1年和5年相对生存率，以及以生存1年为条件的5年相对生存率。对于大多数实体癌，其预后在很大程度上取决于诊断时的分期（乳腺癌、结直肠癌、胃癌、皮肤黑色素瘤），芬兰、瑞典、挪威和冰岛的生存率最高，英国和丹麦较低，捷克共和国、波兰和斯洛文尼亚最低。法国、瑞士和意大利的存活率普遍较高，略低于北方国家。血液系统恶性肿瘤的生存率存在地区间差异，可能是由于有效治疗的可用性不同。老年患者的生存率较低，可能是由于诊断时的晚期、合并症、难以获得或缺乏适当的治疗。对于所有癌症，5年生存率高于1年生存率，且地区差异较小。(C)2008爱思唯尔有限公司保留所有权利。
EUROCARE-4 analysed about three million adult cancer cases from 82 cancer registries in 23 European countries, diagnosed in 1995-1999 and followed to December 2003. For each cancer site, the mean European area-weighted observed and relative survival at 1-, 3-, and 5-years by age and sex are presented. Country-specific 1- and 5-year relative survival is also shown, together with 5-year relative survival conditional to surviving 1-year. Within-country variation in survival is analysed for selected cancers.Survival for most solid cancers, whose prognosis depends largely on stage at diagnosis (breast, colorectum, stomach, skin melanoma), was highest in Finland, Sweden, Norway and Iceland, lower in the UK and Denmark, and lowest in the Czech Republic, Poland and Slovenia. France, Switzerland and Italy generally had high survival, slightly below that in the northern countries. There were between-region differences in the survival for haematologic malignancies, possibly due to differences in the availability of effective treatments.Survival of elderly patients was low probably due to advanced stage at diagnosis, comorbidities, difficult access or lack of availability of appropriate care.For all cancers, 5-year survival conditional to surviving 1-year was higher and varied less with region, than the overall relative survival. (C) 2008 Elsevier Ltd. All rights reserved.