BIOSYNTHESIS OF CARCININE (BETA-ALANYL-HISTAMINE) INVIVO
BIOSYNTHESIS OF CARCININE (BETA-ALANYL-HISTAMINE) INVIVO
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DOI：
10.3109/13813458509079616
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发表时间：
1985-11-01
期刊：
影响因子：
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通讯作者：
ARNOULD, JM
中科院分区：
文献类型：
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作者：
ARNOULD, JM
由Carcinus maenus从[14 C] β-丙氨酸、[14 C]组氨酸和[14 C]组胺。由于肌肽（β-丙氨酰-组氨酸）在蟹组织中不能检测到，致癌素的生物合成只能通过β-组氨酸的直接偶联来实现。由组氨酸脱羧产生的丙氨酸和组胺。当[14 C] β-甲基化时，癌碱的生物合成弱。丙氨酸和[14 C]组氨酸用作前体。相反，当使用[14 C]组胺时，合成是重要的。因此，致癌碱似乎是组胺催化剂的产物。注射[14 C]组胺后，放射性致癌物主要集中在心脏和神经系统，未代谢的[14 C]组胺主要在后者回收。因此，神经系统可能是致癌物生物合成的场所，因此也是组胺的作用部位。
Carcinine was biosynthesized by Carcinus maenus from [14C].beta.-alanine, [14C] histidine and [14C] histamine. Since carnosine (.beta.-alanyl-histidine) could not be detected in crab tissues, biosynthesis of carcinine could only be effected by direct coupling of .beta.-alanine and histamine resulting from histidine decarboxylation. Biosynthesis of carcinine was weak when [14C] .beta.-alanine and [14C] histidine were used as precursors. On the contrary when [14C] histamine was used, synthesis was important. Thus carcinine appears to be a product of histamine catabolism. After injecting [14C] histamine, radioactive carcinine was concentrated mainly in the heart and nervous system; nonmetabolized [14C] histamine was recovered mainly in the latter. The nervous system might therefore be the seat of carcinine biosynthesis and thus the site of action of histamine.