Palladium-catalyzed coupling reaction of fluoroalkylated propargyl mesylates with organozinc reagents: Novel synthesis of optically active fluorine-containing trisubstituted allenes
Palladium-catalyzed coupling reaction of fluoroalkylated propargyl mesylates with organozinc reagents: Novel synthesis of optically active fluorine-containing trisubstituted allenes
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DOI：
10.1246/cl.2000.1360
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发表时间：
2000-12-05
影响因子：
1.6
通讯作者：
Yamanaka, H
中科院分区：
文献类型：
--
作者：
Konno, T;Tanikawa, M;Yamanaka, H
在5摩尔%的四（三苯基膦）钯（0）的存在下。手性氟化炔丙基甲磺酸酯与各种有机锌试剂的反应以高度立体选择性的方式顺利进行，从而以良好的产率得到相应的光学活性含氟三取代联烯，而在反应中没有任何光学纯度的损失。
In the presence of 5 mol% of tetrakis(triphenylphosphine)palladium(0). the reaction of chiral fluorinated propargyl mesylates with a variety of organozinc reagents proceeded smoothly in a highly stereoselective fashion to give the corresponding optically active fluorine-containing trisubstituted allenes in good yields without any loss of optical purity through the reaction.