Activation of the CD95 system increases with disease progression in human immunodeficiency virus type 1-infected children and adolescents.
Activation of the CD95 system increases with disease progression in human immunodeficiency virus type 1-infected children and adolescents.
复制标题
在感染 1 型人类免疫缺陷病毒的儿童和青少年中，CD95 系统的激活随着疾病进展而增加。
DOI：
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复制
发表时间：
1997
期刊：
影响因子：
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通讯作者：
K. Debatin
中科院分区：
文献类型：
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作者：
T. Böhler;C. Bäumler;I. Herr;A. Groll;Marianne Kurz;K. Debatin
背景
在HIV-1感染过程中，CD 4 + T辅助细胞耗竭引起感染和未感染细胞凋亡增加。与健康年龄匹配的对照组相比，以前曾在HIV-1阳性儿童新鲜分离的T细胞中描述过CD 95（APO-1/Fas）和CD 95配体（正常T细胞中细胞凋亡的关键调节因子）表达的强烈增加。我们还发现这些患者的CD 4+和CD 8 + T细胞中自发性和特异性CD 95介导的凋亡增加。然而，这些发现与HIV感染儿童疾病进展的关系尚不清楚。测量和受试者：我们研究了CD 95和CD 95配体的表达，以及对自发和抗CD 95触发的T细胞凋亡的敏感性在33个HIV-1阳性的儿童和青少年在不同的疾病阶段。
结果
体内CD 4 + T细胞的损失被CD 95高T细胞百分比的增加和抗CD 95诱导的CD 4 + T细胞凋亡的增加所抵消。CD 95 L mRNA在中间疾病阶段患者的T细胞中不断上调，而正常CD 4计数的患者和晚期T细胞丢失的患者显示CD 95配体-mRNA水平在正常对照的范围内或略高于正常对照的范围。
结论
CD 95系统的调节紊乱可能在儿童HIV感染过程中免疫缺陷的发展中起重要作用。
BACKGROUND
Increased apoptosis in infected as well as noninfected cells has been invoked in CD4+ T helper cell depletion during HIV-1 infection. A strong increase in the expression of CD95 (APO-1/Fas) and CD95 ligand, key regulators of apoptosis in normal T cells, has previously been described in freshly isolated T cells from HIV-1-positive children when compared with healthy age-matched controls. We also found an increase in spontaneous as well as specific CD95-mediated apoptosis in CD4+ and CD8+ T cells from these patients. However, the relationship of these findings to disease progression in children with HIV infection is not known. MEASUREMENTS AND SUBJECTS: We studied expression of CD95 and CD95 ligand as well as sensitivity towards spontaneous and anti-CD95-triggered apoptosis of T cells in 33 HIV-1-positive children and adolescents in different disease stages.
RESULTS
Loss of CD4+ T cells in vivo was paralleled by an increase in the percentage of CD95 high T cells and an increase in anti-CD95-induced apoptosis of CD4+ T cells. CD95L mRNA was constantly up-regulated in T cells from patients in intermediate disease stages whereas patients with normal CD4 counts and patients with advanced T cell loss showed CD95 ligand-mRNA levels in or slightly above the range of normal controls.
CONCLUSIONS
Disturbed regulation of the CD95 system may play an important role in the development of immunodeficiency during the course of HIV infection in children.
健康儿童、高危儿童和 HIV 感染儿童 T 细胞的激活和分化抗原。
DOI：
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发表时间：
1993
期刊：
Journal of acquired immune deficiency syndromes
影响因子：
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作者：
Plaeger-Marshall,S;Hultin,P;Bertolli,J;O'Rourke,S;Kobayashi,R;Kobayashi,AL;Giorgi,JV;Bryson,Y;Stiehm,ER
通讯作者：
Stiehm,ER
白细胞亚群抗原密度的变化与艾滋病毒疾病的进展相关。
影响因子：
4.4
作者：
Roederer,M;Herzenberg,LA;Herzenberg,LA
通讯作者：
Herzenberg,LA
CD4 分子的交联通过诱导干扰素-γ 和肿瘤坏死因子-α 分泌来上调淋巴细胞中的 Fas 抗原表达。
影响因子：
20.3
作者：
Oyaizu,N;McCloskey,TW;Than,S;Hu,R;Kalyanaraman,VS;Pahwa,S
通讯作者：
Pahwa,S